This is the first book comprising all relevant aspects for the clinical application of biologics. All biologics currently approved for clinical use are described in a standardized way concentrating on practically relevant aspects such as contra-indications or monitoring needs. The "differential therapy" with biologics namely in the fields of dermatology, rheumatology, gastroenterology, and neurology is described in detail and summarized in treatment algorithms. Shorter sections on the biotechnology behind the biologics as well as safety, regulatory, and pharmaco-economic aspects complement the more clinically-oriented central chapters.
1;Preface;5 2;Contents;6 3;List of Contributors;13 4;Introduction: Definition and Classification of Biologics;17 5;Development and Pre- clinical Pharmacology of Biologics;19 5.1;Infliximab: From the Idea to the Product ;20 5.2;Adalimumab;29 5.3;Etanercept;47 5.4;Efalizumab: Antibody Characteristics, Mode of Action and Preclinical Development;57 5.5;Monoclonal Antibody Targeted Radiation Cancer Therapy;65 5.6;The Production of Biopharmaceuticals;74 6;Disease- Specific Applications and Clinical Trials;82 6.1;Treating Autoimmune Bullous Skin Disorders with Biologics;83 6.2;Biologics in Psoriasis;95 6.3;Biologic Agents in Psoriatic Arthritis;111 6.4;Biologic Therapies for Rheumatoid Arthritis Targeting TNF- a and IL- 1;125 6.5;Biologics in Crohn's Disease and Ulcerative Colitis: Focus on Tumor Necrosis Factor Antagonists;138 6.6;Multiple Sclerosis: New Immunobiologics;155 6.7;Biologics in Cutaneous Lymphoma;161 6.8;Biologics in Targeted Cancer Therapy;167 7;Safety and Perspectives;180 7.1;Safety Aspects of Biologics: Lessons Learnt from Monoclonal Antibodies;181 7.2;New Biological Therapeutics in the Genome Age ;187 7.3;Evidence Based Medicine's Perspective on Biologics;196 8;Subject Index;199
Boehncke, Wolf-Henning
Radeke, Heinfried
| ISBN | 9783540290186 |
|---|---|
| Article number | 9783540290186 |
| Media type | eBook - PDF |
| Edition number | 2. Aufl. |
| Copyright year | 2007 |
| Publisher | Springer-Verlag |
| Length | 190 pages |
| Language | English |
| Copy protection | Digital watermarking |
