Cell-Penetrating Peptides
Design, Development and Applications
The modern reference on the rational design and development of cell-penetrating peptides (CPPs) for use in cellular delivery of drugs and various other cargoes.
Introduction
Introduction
PART 1: DESGIN OF CPPS
Classification of cell-penetrating peptides
Arginine-rich cell-penetrating peptides: recent advances of design and applications for intracellular delivery
Cationic cell-penetrating peptides
Amphipathic cell-penetrating peptides
Hydrophobic cell-penetrating peptides
Foldamers
PART 2: MECHANISM OF CPPS
Peptide Structure: Electrophysiological analysis, nuclear magnetic resonance analysis, and molecular dynamics simulation of direct penetration of cell-penetrating peptides through bilayer lipid membranes
Cellular uptake mechanisms of arginine-rich cell-penetrating peptides
Endosomal escape
Pharmacokinetics of therapeutic and diagnostic agents conjugated with cell-penetrating peptides
PART 3: DELIVERY TOOLS
Drug delivery
Peptide & protein delivery
Cell-penetrating peptides for nucleic acid delivery
PPMOs: a case study for cell-penetrating peptide application
Cell penetrating peptide-conjugated polymer micelles for pDNA/siRNA delivery
Lipid-based nanoparticles using cell-penetrating peptides
PART 4: APPLICATIONS
Cell-penetrating peptides as tools to facilitate oral delivery of biopharmaceuticals
Intranasal delivery
Clinical trials
Applications in plants
| ISBN | 9783527350117 |
|---|---|
| Article number | 9783527350117 |
| Media type | Book |
| Edition number | 1. Auflage |
| Copyright year | 2023 |
| Publisher | Wiley-VCH |
| Length | 416 pages |
| Illustrations | 1 Farbabb. |
| Language | English |
