Long Circulating Liposomes: Old Drugs, New Therapeutics

Long Circulating Liposomes: Old Drugs, New Therapeutics

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This book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.

1. Long Circulating Liposome Therapeutics: From Concept to Clinical Reality
2. Oncologic Agents in Sterically Stabilized Liposomes: Basic Considerations
3. Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations
4. Long Circulating Liposome-Encapsulated Tumor Necrosis Factor in the Treatment of Solid Tumors
5. Therapy of Human Carcinoma Xenografts with Doxorubicin Encapsulated in Sterically Stabilized Liposomes (DOXIL®): Efficacy and Safety Studies
6. Design and Development of Long Circulating Liposomal Daunorubicin for In Vivo Targeting of Solid Tumors: DaunoXome®
7. Enhancement of Doxorubicin by Encapsulation in Long circulating Thermosensitive Liposomes Combined with Local Hyperthermia
8. Liposomal Localization and Chemotherapy for AIDS-Related Kaposi's Sarcoma
9. Pegylated-Liposomal Doxorubicin (Doxil®) in the Treatment of AIDS-Related Kaposi's Sarcoma
10. DaunoXome® (Liposomal Daunorubicin) for First-Line Treatment of Advanced, HIV-Related Kaposi's Sarcoma
11. Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors
12. Antibacterial Therapy with Sterically Stabilized Liposome Formulations
13. AmBisome®: Long Circulating Liposomal Formulation of Amphotericin B
14. Steric Stabilization of Liposomes Containing Amphotericin B: A Future Direction in Antifungal Therapy?
15. Clinical and Preclinical Studies with Low-Clearance Liposomal Amikacin (MiKasome®)
16. Sterically Stabilized Liposomes to Image Infection and Inflammation
17. Long Circulating Liposomes for Diagnostic Imaging
18. Tumor Imaging with Long Circulating Liposomes
19. Antibody-Mediated Targeting of PEG-Coated Liposomes
20. Small Molecule Ligands for Targeting LongCirculating Liposomes.
ISBN 978-3-662-22117-4
Article number 9783662221174
Media type Book
Edition number Softcover reprint of the original 1st ed. 1998
Copyright year 2013
Publisher Springer, Berlin
Length XX, 301 pages
Illustrations XX, 301 p. 34 illus.
Language English