Molecular Biology in Medicinal Chemistry

Molecular Biology in Medicinal Chemistry

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Die Gentechnik hat nicht nur die moderne Biologie sondern auch die Pharmaforschung revolutioniert. Dieser Band beschreibt anhand vielfältiger Beispiele die erfolgreiche Anwendung molekularbiologischer Methoden bei der Entwicklung, Herstellung und Analytik von pharmazeutischen Wirkstoffen.
Renommierte Herausgeber und Autoren beleuchten den aktuellen Stand der Forschung und erläutern die Möglichkeiten und Grenzen der neuen Verfahren. Dieses verständlich geschriebene Buch wendet sich an alle Chemiker, Pharmazeuten, Molekularbiologen und Mediziner, die sich mit der modernen Wirkstoffforschung beschäftigen.

MOLECULAR TARGETS
Cellular Assays in Drug Discovery
Gene Knockout Models
Reporter Gene Assay Systems for the Investigation of GPCRs
From the Human Genome to New Drugs: The Potential of Orphan GPCRs
SYNTHESIS
Stereoselective Synthesis with the Help of Recombinant Enzymes
Nucleic Acid Drugs
ANALYSIS
Recent Trends in Enantioseparation of Chiral Drugs
Affinity Chromatography
NMR-based Drug Discovery
13C- and 15N-Isotopic Labeling of Proteins
Antibody Fragments as Crystallization Enhancers
KINETICS, METABOLISM AND TOXICOLOGY
Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response
Pharmacogenomics of Bioavaliability and Elimination
Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology


MOLECULAR TARGETS
Cellular Assays in Drug Discovery
Gene Knockout Models
Reporter Gene Assay Systems for the Investigation of GPCRs
From the Human Genome to New Drugs: The Potential of Orphan GPCRs
SYNTHESIS
Stereoselective Synthesis with the Help of Recombinant Enzymes
Nucleic Acid Drugs
ANALYSIS
Recent Trends in Enantioseparation of Chiral Drugs
Affinity Chromatography
NMR-based Drug Discovery
13C- and 15N-Isotopic Labeling of Proteins
Antibody Fragments as Crystallization Enhancers
KINETICS, METABOLISM AND TOXICOLOGY
Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response
Pharmacogenomics of Bioavaliability and Elimination
Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology
ISBN 9783527304318
Article number 9783527304318
Media type Book
Edition number 1. Auflage
Copyright year 2003
Publisher Wiley-VCH
Length XXII, 413 pages
Illustrations 104 SW-Abb., 9 Farbabb., 32 Tabellen
Language English