The First Adalat Symposium held in Tokyo in 1973, presented important experimental and clinical results which had been collected in Europe and Japan with the new coronary therapeutic agent. The European scientists had an opportunity to discuss the problems and results personally with their Japanese colleagues. The Second Adalat Symposium was held in Amsterdam within a year with the purpose of bringing together mainly scientists within Europe. The results discussed in Tokyo have been extended and supplemented through additional experiences. Contributions in basic science are presented, but most important are those clinical studies, which support and extend proof of the drug's efficacy in humans. The editors wish to express their appreciation to all those responsible for contributing to this report and, in particular, to Dr. M. SPENGLER, Dr. F. EBNER and Dr. K. BRANDAU for their editorial help, and to Dr. W. BOTTGER for the preparation of the Subject Index. We hope that this publication will be a valuable contribution toward conveying information to physicians and scientists. DiisseldorfjWuppertal, Autumn 1975 W. LOCHNER' W BRAASCH' G. KRONEBERG Contents Introduction: W. LOCHNER Present Basis of Coronary Therapy: W. LOCHNER. With 11 Figures 2 Session I. Chemistry and Experimental Pharmacology (Chairmen: A. FLECKENSTEIN and K. LANDMARK) Pharmacology of Nifedipine: G. KRONEBERG. With 8 Figures 12 Discussion Remarks 19 The Chemistry of Nifedipine: F. BOSSERT. With 9 Figures 20 Pharmacokinetics of Adalat in Animal Experiments: K. PATZSCHKE, B.

Present Basis of Coronary Therapy

Session I. Chemistry and Experimental Pharmacology
Pharmacology of Nifedipine
The Chemistry of Nifedipine
Pharmacokinetics of Adalat in Animal Experiments
Investigations on the Metabolism and Protein Binding of Nifedipine
Experimental Pharmacological Investigations of Effects of Nifedipine on Atrioventricular Conduction in Comparison with Those of Other Coronary Vasodilators
Studies on the Extracardial Effects of Nifedipine in Anesthetized Dogs
Session II. Experimental Pharmacology
Adalat, a Powerful Ca-Antagonistic Drug
Ca-Dependent Changes in Coronary Smooth Muscle Tone and the Action of Ca-Antagonistic Compounds with Special Reference to Adalat
Myocardial Oxygen Consumption under the Influence of Nifedipine (Adalat) in the Anesthetized Dog
Hemodynamic Effects of Adalat in the Unanesthetized Dog
Investigations on the Development of Collaterals, Coronary Flow, Tachyphylaxis and Steal Phenomenon in Dogs after Application of Adalat
The Effect of Adalat on the Mechanical and Electrical Activity of Isolated Rat Cardiac Muscle, with Special Reference to Calcium Antagonism of the Compound
Session III. Clinical Pharmacology
Hemodynamic Studies on Adalat in Healthy Volunteers and in Patients
Pharmacokinetics of Nifedipine-14C in Man
Hemodynamic Studies on the New Coronary Therapeutic Drug Nifedipine (BAY a 1040)
Effect of Nifedipine (Adalat) on Myocardial Oxygen Extraction and Lactate Metabolism and ST-T Segment Changes in Patients with Coronary Insufficiency during Artificial Stimulation of the Heart
Hemodynamic Effect of Nifedipine (Adalat) in Patients Catheterized for Coronary Artery Disease
Session IV. Clinical Pharmacological Efficacy
Comparison of the Effects of Adalat with Other Substances onthe Myocardial Ischemia under Loading Conditions
Left Ventricular Hemodynamics in Patients at Rest before and after Nifedipine (Adalat)
Adalat and Beta Blockers; the Mechanism Studied with Two Series of Work Tests in Two Groups of Patients with Angina Pectoris
Adalat (Nifedipine) under Loading Conditions
Results of a Comparative Study with Adalat: Phonomechano-Cardiograms in Normal Persons and Patients with Coronary Heart Disease
Myocardial Circulation under Adalat in Different Phases of Coronary Diseases
Session V. Clinical Aspects: Hemodynamics, Onset and Duration
Coronary and Left Ventricular Dynamics under Nifedipine in Comparison to Nitrates, Beta-Blocking Agents and Dipyridamole
Effect of Adalat (Nifedipine) on Left Ventricular Hemodynamics in Angina Pectoris (Comparative Study with Propranolol)
The Effect of Adalat on Coronary Circulation after Sublingual Administration
Loading Tolerance after Adalat and Duration of Effect in Postmyocardial Infarction Studied in a Double-Blind Trial
The Cardiopulmonary Loading Capacity in Healthy Persons and Patients with Coronary Heart Disease after Application of Adalat
Remarks on Changes of ST Segment Depression during the Day
Hemodynamic Study of Nifedipine Using Doppler Flowmetry
Session VI. Clinical Aspects: Special Studies
Clinical-Therapeutic and Hemodynamic Studies with Adalat, a New Coronary Active Substance
Influence of Different Doses of Adalat on Angina Pectoris Induced by Exercise
Nifedipine in the Treatment of Ischemic Heart Disease
Clinical Observations on the Efficacy of Adalat Compared with a Pentaerythrityl Tetranitrate Preparation
Clinical Studies on the Combined Effect of Various Antihypertensive Agents and Adalat
Response of Intraocular Pressure in Normal Subjects andGlaucoma Patients to Single and Repeated Doses of the Coronary Drug Adalat
Extracardial Effects of Nifedipine (Adalat): Measurements of Liver Blood Flow in Animals and Humans and of Peripheral Circulation in the Lower Limbs
The Influence of Adalat on Pulmonary Pressure
Comparison of the Effect of Adalat and Propranolol on Exercise Tolerance in Patients with Angina Pectoris
Session VII. Clinical Aspects: Proof of Clinical Efficacy
Nifedipine in Angina Pectoris: A Multicentric Clinical Trial
An Interim Report on a Cooperative Double-Blind Clinical Trial with Nifedipine
Results of a Double-Blind Study with Adalat under Short- and Long-Term Treatment
Long-Term Therapy with Adalat. A Preliminary Report
Survey and Summary of Results Obtained during the World-Wide Clinical Investigations of Adalat (Nifedipine)
Closing Remarks.