The first edition to A Guide to Bone Marrow Transplantation was published 10 years ago. At that time we perceived a need for an introductory text to the area of marrow transplantation, a rapidly developing field with few general texts avail able. Since then the situation has changed dramatically. Several introductory texts, therapeutic manuals and comprehensive volumes have been published. There is a heightened awareness of the availability, utility and potential of bone marrow transplantation, and of peripheral blood stem cell transplantation in particular. In many cases stem cell transplantation is being practiced by physi cians as a standard therapy. For those reasons we weighed carefully the question whether the Guide was still useful or even had a place. The feedback we received from physicians in practice or in training (including both hematologists and other physicians), as well as from nurses, physician's assistants, nurse practitioners, and other personnel in volved in one way or another in hematopoietic stem cell transplantation indicat ed that such a text was still desirable as an introduction that focused on princi ples rather than the latest up-to-date results.

I. Pretransplant Considerations

1. Rationale and Indications for Transplantation
2. Timing of Transplantation
3. Stem Cell Sources
4. Preparation for Stem Cell Transplantation
5. Cost Considerations
II. Transplant Procedure
1. Conditioning Regimens
2. Collection and Processing of Stem Cells
3. In Vitro Expansion of Stem Cells
4. Genetic Manipulation of Hematopoietic Stem Cells
5. Prevention and Treatment of Relapse
III. Transplant-Related Problems
1. Side Effects of Conditioning Regimens
2. Graft Failure
3. Graft-Versus-Host Disease
4. Management of Infections
5. Single and Multi-Organ Failure
6. Chronic Graft-Versus-Host Disease
7. Delayed Complications
IV. Long-Term Follow-Up
1. Follow-Up After Discharge from the Transplant Center
2. Rehabilitation
QuoVadis?
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