Accelerated Partial Breast Irradiation
Techniques and Clinical Implementation
E-Book
Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text is a concise handbook designed to assist the clinician in the implementation of APBI. This includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications.
1;Contents;5 2;Contributors;15 3;Accelerated Partial Breast Irradiation: History, Rationale, and Controversies;19 3.1;1.1 Introduction;19 3.2;1.2 History of APBI;22 3.3;1.3 Controversies Regarding the Use of APBI;25 3.4;1.4 Conclusions;31 3.5;References;32 4;Who Is a Candidate for APBI?;36 4.1;2.1 Introduction;36 4.2;2.2 Pathologic Data;38 4.3;2.3 Anatomic Patterns of In-Breast Failure After Breast-Conserving Treatment;39 4.4;2.4 Proper Selection Criteria;40 4.5;References;47 5;Pathologic Anatomy of Early-Stage Breast Cancer and Its Relevance to APBI: Defining the Target;52 5.1;3.1 Determining the Extent of Disease Beyond the Lumpectomy Cavity;52 5.2;3.2 Impact of Radiation on Local Recurrences;58 5.3;3.3 Conclusions;60 5.4;References;60 6;The Radiobiology of Accelerated Partial Breast Irradiation;63 6.1;4.1 General Radiobiology Principles;64 6.2;4.2 The Radiobiology of Breast Cancer;65 6.3;4.3 Intraoperative APBI;66 6.4;4.4 External-Beam APBI;67 6.5;4.5 Interstitial Implant APBI;68 6.6;4.6 Conclusion;70 6.7;References;71 7;Surgical Considerations in Partial Breast Irradiation;74 7.1;5.1 Introduction;74 7.2;5.2 Patient Selection;75 7.3;5.3 Tumor Location;75 7.4;5.4 Cavity Shape and Size;78 7.5;5.5 Technical Considerations;82 7.6;5.6 Impact of Oncoplastic Techniques on the Use of APBI;86 7.7;References;87 8;Physics of Accelerated Partial Breast Irradiation;88 8.1;6.1 Introduction;88 8.2;6.2 Interstitial Brachytherapy;89 8.3;6.3 Intracavitary Volume Implants;94 8.4;6.4 External Beam;110 8.5;References;114 9;Quality Assurance for Accelerated Partial Breast Irradiation;116 9.1;7.1 Quality Management for Breast Brachytherapy;116 9.2;7.2 Quality Management for External-Beam Partial Breast Irradiation;135 9.3;References;138 10;Overview of North American Trials;140 10.1;8.1 Introduction;140 10.2;8.2 Patient Selection;141 10.3;8.3 Interstitial Technique;142 10.4;8.4 Tufts/Brown/Rhode Island;146 10.5;8.5 MammoSite Balloon;150 10.6;8.6 External-Beam APBI;157 10.7;8.7 Conclusion;161 10.8;References;162 11;An Overview of European Clinical Trials of APBI;165 11.1;9.1 Introduction;165 11.2;9.2 Early European APBI Trials;165 11.3;9.3 Contemporary European APBI Trials;170 11.4;9.4 European MammoSite Brachytherapy Trials;177 11.5;9.5 European (GEC-ESTRO) Multicentric Randomized APBI Trial;181 11.6;9.6 Summary and Future Directions;183 11.7;References;184 12;The Phase III Trials: Obtaining Definitive Answers;187 12.1;10.1 Patient Selection and Study Eligibility;193 12.2;10.2 Target Delineation;194 12.3;10.3 Technique and Dosimetry;198 12.4;10.4 Quality Assurance;199 12.5;10.5 Conclusion;200 12.6;References;200 13;The Virginia Commonwealth University Technique of Interstitial Brachytherapy;202 13.1;11.1 History;202 13.2;11.2 Implantation Technique;204 13.3;11.3 Dosimetric Guidelines;210 13.4;11.4 Results;212 13.5;11.5 Conclusion;213 13.6;References;214 14;Accelerated Partial Breast Irradiation: The William Beaumont Hospital Technique of Interstitial Brachytherapy;216 14.1;12.1 History;216 14.2;12.2 Physics;217 14.3;12.3 Implantation Technique;218 14.4;12.4 Clinical Results;225 14.5;12.5 Future Directions;228 14.6;References;229 15;Brachytherapy Techniques: The Arizona Approach;232 15.1;13.1 Introduction: A 17-Year Historical Perspective on the Evolution of Accelerated Partial Breast Irradiation;232 15.2;13.2 A New Hypothesis and a Potential Paradigm Shift;235 15.3;13.3 The Target Volume;236 15.4;13.4 Irradiating the Target Volume;237 15.5;13.5 Brachytherapy Techniques;238 15.6;13.6 Judgment: Selecting the Optimal Technique for a Particular Patient;255 15.7;13.7 Summary;257 15.8;References;258 16;The MammoSite Technique for Accelerated Partial Breast Irradiation;260 16.1;14.1 History of the Applicator;260 16.2;14.2 MammoSite and the FDA Trial;261 16.3;14.3 Physics of the MammoSite;263 16.4;14.4 Single Dwell vs. Multidwell;264 16.5;14.5 Elliptical MammoSite;266 16.6;14.6 Contrast Effect;266 16.7;14.7 Implantation Techniques;266 16.8;14.8 Other Cons
Wazer, David E.
Arthur, Douglas
Vicini, Frank
| ISBN | 9783540880066 |
|---|---|
| Artikelnummer | 9783540880066 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2009 |
| Verlag | Springer-Verlag |
| Umfang | 436 Seiten |
| Sprache | Englisch |
| Kopierschutz | Adobe DRM |
