Acute Neuronal Injury
The Role of Excitotoxic Programmed Cell Death Mechanisms
Acute Neuronal Injury
The Role of Excitotoxic Programmed Cell Death Mechanisms
An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death.
The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
To survive or to die: how neurons deal with it
Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches
Mitochondrial damage in traumatic CNS injury
Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury
Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia
Apoptosis-inducing factor translocation to nuclei after transient global ischemia
Necroptosis in cerebral ischemia
Histological and elemental changes in ischemic stroke
Hypoglycemic brain damage
Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis
Conclusion.</p>
The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
<p>Introduction
Excitotoxic programmed cell death involves caspase-independent mechanismsTo survive or to die: how neurons deal with it
Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches
Mitochondrial damage in traumatic CNS injury
Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury
Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia
Apoptosis-inducing factor translocation to nuclei after transient global ischemia
Necroptosis in cerebral ischemia
Histological and elemental changes in ischemic stroke
Hypoglycemic brain damage
Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis
Conclusion.</p>
Fujikawa, Denson G.
ISBN | 978-3-030-08468-4 |
---|---|
Artikelnummer | 9783030084684 |
Medientyp | Buch |
Auflage | 2. Aufl. |
Copyrightjahr | 2018 |
Verlag | Springer, Berlin |
Umfang | XII, 215 Seiten |
Abbildungen | XII, 215 p. 39 illus., 24 illus. in color. |
Sprache | Englisch |