Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development  of targeted therapy.

APL as a Paradigm in Biomedical Research: A Journey Toward the Cure

Mouse Models of Acute Promyelocytic Leukemia
The PLZF Gene of t(11;17)-Associated APL
SUMO, the Three Rs and Cancer
Emerging Role for MicroRNAs in Acute Promyelocytic Leukemia
The Theory of APL Revisited
Treatment of Acute Promyelocytic Leukemia by Retinoids
Arsenic Trioxide and Acute Promyelocytic Leukemia: Clinical and Biological
Front Line Clinical Trials and Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia
Histone Deacetylase Inhibitors in APL and Beyond
Monoclonal Antibody Therapy of APL
Targeting APL Fusion Proteins by Peptide Interference
The Design of Selective and Non-selective Combination Therapy for Acute Promyelocytic Leukemia.