These are the proceedings of the third Asian Pacific Adalat Symposium. The first was held in Tokyo in 1982 and the second in Sydney in 1985. We were honoured that the late Dr. Sukaman and his colleagues were able to host this third symposium in Jakarta. This meeting was designed to contribute to and to promote international collaboration in cardiovascular research, and to help promote further knowledge and understanding about the treatment of vascular disease in the Asian Pacific area. Nifedipine was originally investigated in the mid-1960s by Prof. Fleckenstein. His first results showed this drug was a powerful calcium antagonist which altered excitation contraction. At this time, there was a rapid development of knowledge about the pathophysiology of ischaemic heart disease, and thus the important pharmacological work on calcium antagonists such as nifedipine paralleled and complimented the newer understanding of coronary physiology in man. In a short time most therapy was designed to reduce myocardial oxygen consumption and demand.

Ischemic Heart Disease

Study on the Clinical Effectiveness of Adalat L Tablet for Angina Pectoris: A Double-blind Study with Adalat as a Reference Drug
Nifedipine-induced Reperfusion in Stable Angina and Postimfarction Cases
Newest Information on Unstable Angina Pectoris
Effect of Nifedipine on Relaxation and Early Left Ventricular Filling During Postpacing Ischemic Period
Atherosclerosis
Effect of Nifedipine on Atherosclerosis in Cholesterol-Fed Rabbits and Watanabe Heritable Hyperlipidemic Rabbits
Natural History of Coronary Artery Disease: The Effects of Ca2+ Channel Blockade and Antiplatelet Agent on Progression or Regression of Coronary Atherosclerosis
Effect of Nifedipine on DNA Synthesis and Cytosolic Free Calcium Concentration Stimulated by Growth Factors: A Study Using Cultured Rat Aortic Smooth-Muscle Cells
Hypertension
Studies on the Mechanism of the Antihypertensive Effect of Long-Term Administered Nifedipine in Patients with Benign Essential Hypertension
Nifedipine Retard as Monotherapy for Essential Hypertension: A Randomized Controlled Cross-over Study
Long-Term Treatment of Hypertensive Patients with Nifedipine Tablet
Hemodynamic and Neurohumoral Effects of Nifedipine Slow-Release Tablet in the Treatment of Hypertension
Special Topics
Effect of Nifedipine on Serum Lipoprotein Metabolism in Patients with Essential Hypertension
Effects of Nifedipine on Cardiovascular System, with Special Reference to Coronary Circulation.