Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

to Adenosine Receptors as Therapeutic Targets

A1 Adenosine Receptor Antagonists, Agonists, and Allosteric Enhancers
Recent Developments in Adenosine A2A Receptor Ligands
Recent Developments in A2B Adenosine Receptor Ligands
Medicinal Chemistry of the A3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering
Adenosine Receptors and the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology
Adenosine Receptors and Reperfusion Injury of the Heart
Adenosine Receptors and Inflammation
A1 Adenosine Receptor: Role in Diabetes and Obesity
A3 Adenosine Receptor: Pharmacology and Role in Disease
Adenosine Receptors and Asthma
Adenosine Receptors, Cystic Fibrosis, and Airway Hydration
Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis
Adenosine Receptors and Cancer
Adenosine Receptors and the Kidney
Adenosine Receptors and the Central Nervous System
Adenosine Receptors and Neurological Disease: Neuroprotection and Neurodegeneration
Adenosine A2A Receptors and Parkinson's Disease
Adenosine Receptor Ligands and PET Imaging of the CNS.