After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.

List of Contents

1 Virion and Structure
Molecular Evolution of Adenoviruses
Novel Partner Proteins of Adenovirus Penton
Structural Studies on Adenoviruses
2 Viral Replication
The Multifunctional Role of E1A in the Transcriptional Regulation of CREB/CBP-Dependent Target Genes
Adenovirus DNA Replication
Regulation of Adenovirus Packaging
Adenovirus DNA Replication: Protein Priming, Jumping Back and the Role of the DNA Binding Protein DBP
The Structure and Function of the Adenovirus Major Late Promoter
3 Host-Cell Interactions
Remodelling of the Host Cell RNA Splicing Machinery During an Adenovirus Infection
Regulation of mRNA Production by the Adenoviral E1B 55-kDa and E4 Orf6 Proteins
Adenovirus Interaction with Its Cellular Receptor CAR
Transactivation of Human cdc2 Promoter by Adenovirus E1A
Nuclear Perturbations Following Adenovirus Infection
The Abortive Infection of Syrian Hamster Cells with Human Adenovirus Type 12.