This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2020, held in São Paulo, Brazil, in November 2020. Due to COVID-19 pandemic the conference was held virtually
The 20 revised full papers and 5 short papers were carefully reviewed and selected from 45 submissions. The papers address a broad range of current topics in computational biology and bioinformatics.

A Classification of de Bruijn Graph approaches for De Novo Fragment Assembly<b>

</b>Redundancy Treatment of NGS Contigs in Microbial Genome Finishing with Hashing-Based Approach<b>
</b>Efficient Out-of-core Contig Generation<b>
</b>In silico Pathogenomic Analysis of Corynebacterium pseudotuberculosis biovar ovis<b>
</b>Assessing the sex-related genomic composition diffeerence using a K-mer-based approach: a case of study in Arapaima gigas (Pirarucu)<b>
</b>COVID-19 X-ray Image Diagnostic with Deep Neural Networks<b>
</b>Classification of Musculoskeletal Abnormalities with Convolutional Neural Networks
Combining mutation and gene network data in a machine learning approach for false-positive cancer driver gene discovery<b>
</b>Unraveling the role of Nanobodies Tetrad on their Folding and Stability Assisted by Machine and Deep Learning Algorithms<b>
</b>Experiencing DfAnalyzer for Runtime Analysis of Phylogenomic Dataows
Sorting by Reversals and Transpositions with Proportion Restriction<b>
</b>Heuristics for Breakpoint Graph Decomposition with Applications in Genome Rearrangement Problems<b>
</b>Center Genome With Respect to the Rank Distance<b>
</b>ImTeNet: Image-Text Classification Network for Abnormality Detection and Automatic Reporting on Musculoskeletal Radiographs<b>
</b>A scientometric overview of bioinformatics tools in the Pseudomonas putida genome study<b>
</b>Polysome-seq as a Measure of Translational Profile from Deoxyhypusine Synthase Mutant in Saccharomyces cerevisiae<b>
</b>Anti-CD3 stimulated T cell transcriptome reveals novel ncRNAs and correlates with a suppressive profile<b>
</b>A simplified complex network-based approach to mRNA and ncRNA transcript classification<b>
</b>A systems biology driven approach to map the EP300 interactors using comprehensive protein interaction network<b>
</b>Analyzing switch regions of human Rab10 by molecular dynamics simulations<b>
</b>Importance of meta-analysis in studies involving plant responses to climate change in Brazil<b>
</b>A brief history of Bioinformatics told by data visualization<b>
</b>Computational Simulations for Cyclizations Catalyzed by Plant Monoterpene Synthases<b>
</b>Oncogenic signaling pathways in Mucopolysaccharidoses<b>
</b>Natural products as potential inhibitors for SARS-CoV-2 papain-like protease: an in silico study<b>.</b>