1;Foreword;6 2;Preface;7 3;Contents;8 4;1 Pretreatment Considerations;11 4.1;1.1 Molecular Biology and Genetics of Lung Cancer;12 4.2;1.2 Angiogenesis and Lung Cancer;21 4.3;1.3 Contemporary Issues in Staging of Lung Cancer;39 5;2 Basic Treatment Considerations;53 5.1;2.1 Lung Cancer Surgery;54 5.2;2.2 Radiation Therapy;66 5.2.1;2.2.1 Radiobiology of Normal Lung Tissue and Lung Tumours;66 5.2.2;2.2.2 Radiation Time, Dose, and Fractionation in the Treatment of Lung Cancer;73 5.2.3;2.2.3 Treatment Planning and Conformal Radiotherapy;82 5.2.4;2.2.4 Target Volumes in Non-Small Cell Lung Cancer;101 5.2.5;2.2.5 Target Volumes in Small Cell Lung Cancer;115 5.2.6;2.2.6 Radioprotectors and Chemoprotectors in the Management of Lung Cancer;126 5.3;2.3 Lung Cancer Chemotherapy for Radiation Oncologists;138 5.4;2.4 Radiotherapy and Chemotherapy;158 6;3 Current Treatment Strategies in Non- Small Cell Lung Cancer;170 6.1;3.1 Early Stage in Non-Small Cell Lung Cancer;171 6.1.1;3.1.1 Radiotherapy in Early Stage Non-Small Cell Lung Cancer;171 6.1.2;3.1.2 Postoperative Radiotherapy for Non- Small Cell Lung Carcinoma;191 6.1.3;3.1.3 Photodynamic Therapy;201 6.2;3.2 Locally Advanced Non-Small Lung Cancer;208 6.2.1;3.2.1 Radiochemotherapy in Locally Advanced Non-Small Cell Lung Cancer;208 6.2.2;3.2.2 Chemotherapy or Chemoradiotherapy Followed by Surgical Resection for Non- Small Cell Lung Cancer;224 6.2.3;3.2.3 Palliative External Beam Thoracic Radiotherapy;248 6.2.4;3.2.4 Intraoperative Electron Beam Radiotherapy in Lung Cancer;256 6.2.5;3.2.5 Intraluminal Radiotherapy;270 7;4 Treatment of Small- Cell Lung Cancer;276 7.1;4.1 Limited-Disease of Small Cell Lung Cancer;277 7.2;4.2 Prophylactic Cranial Irradiation in Small Cell Lung Cancer;287 8;5 Radiation Therapy for Recurrent Lung Cancer;296 9;6 Radiotherapy for Lung Cancer in Elderly Patient;307 10;7 Advances in Supportive and Palliative Care for Lung Cancer Patients;319 11;8 Treatment-Related Toxicity;335 11.1;8.1 Hematologic Toxicity in Lung Cancer;336 11.2;8.2 Radiation-Induced Lung and Heart Toxicity;348 11.3;8.3 Spinal Cord;363 11.4;8.4 Radiation Therapy-Related Toxicity: Esophagus;369 11.5;8.5 Brain Toxicity;379 12;9 Quality of Life in Radiation Oncology of Lung Cancer;390 13;10 Prognostic Factors in Lung Cancer;405 14;11 Future Strategies in Lung Cancer;415 14.1;11.1 Intensity-Modulated Radiation Therapy for Lung Cancer;416 14.2;11.2 Stereotactic Radiotherapy and Gated Therapy;427 14.3;11.3 Novel Substances in the Treatment of Lung Cancer for the Radiation Oncologist;438 14.4;11.4 PET Scanning in Staging and Evaluation of Response to Treatment in Lung Cancer;452 14.5;11.5 Heavy Particles in Lung Cancer;463 14.6;11.6 Translational Research in Radiation Oncology of Lung Cancer;470 15;12 Pitfalls in the Design, Conduct and Analysis of Randomised Clinical Trials;483 16;13 New Directions in the Evaluation and Presentation of Clinical Research in Lung Cancer;492 17;Subject Index;500 18;List of Contributors;503