This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches.

AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. 

This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.

Emily Y. Chew is the Director of the Division of Epidemiology and Clinical Applications (DECA), at the National Eye Institute, the National Institutes of Health in Bethesda, Maryland. She is also the Chief of the Clinical Trials Branch. Emily received her medical degree and her ophthalmology training at the U. of Toronto, School of Medicine, in Toronto, Canada. She completed her fellowship in Medical Retina at the Wilmer Eye Institute, the Johns Hopkins Medical Institutes and the U. of Nijmegen, the Netherlands. 

Emily Chew has been recognized for her scientific accomplishments, and mentoring efforts by the National Institutes of Health and numerous professional societies in the area of retinal research.

Dr. Anand Swaroop obtained his Ph.D. in Biochemistry at the Indian Institute of Science, Bangalore, India.  After his postdoctoral training at Yale University, he joined the faculty at the University of Michigan in the Departments of Ophthalmology and in Human Genetics in 1990 and held the Harold F. Falls Collegiate Professorship from 2003-07. Dr. Swaroop was recruited to establish Neurobiology-Neurodegeneration and Repair Laboratory at the National Eye Institute, NIH, in 2007 to advance research in all aspects of retinal biology, disease and therapies.  

The studies in Swaroop laboratory have focused primarily on genetic and epigenetic regulation of photoreceptor development and aging, genetics of inherited retinal diseases and of age-related macular degeneration, and design of new therapeutic paradigms using cell, gene or small molecule-based approaches.

Dr. Swaroop is leader in the field of retinal development and degeneration and has received many awards for his contributions. He has published almost 350 peer-reviewed articles and reviews (Scopus h-index=71), and delivered 300 invited lectures including named and keynote talks worldwide. Dr. Swaroop routinely reviews for many prestigious journals, contributes to institutional committees for promotions and tenure, and evaluates grants for national and international funding agencies.