This book, written by leading international experts, describes alternate fractionation strategies in which technology-driven precise targeting and dosing allow for improved conformance and decreased volumes, with concordant lessening of toxicity, reduction in treatment time, and lower overall health care expense. The aim is to provide the advanced clinician with an up-to-date evidence-based reference that will assist in the delivery of enhanced patient care in daily practice.

Traditional multi-week fractionation schedules were established at a time when the inclusion of relatively large amounts of normal tissue was unavoidable owing to the lack of accurate target localization during treatment. Such schedules are time and resource consuming, difficult for patients, and expensive. Nevertheless, acceptance of alternate fractionation strategies has been slow in some countries. The paradigm is, however, changing as evidence accumulates to demonstrate improved local control, equivalence of tolerance, or both. In documenting these alternate strategies, this book will be of value for radiation oncologists, medical physicists, and oncologists worldwide.

Dedication.- 1 Introduction

2 Historical Development of Alternate Fractionation Schema
3 Radiobiology of Alternate Fractionation
4 Technological advances enabling Alternate Fractionation
a Beam delivery
b Imaging Technology
c Treatment Planning
5 Workflow and Quality Assurance in Alternate Fractionation
6 The Future of Alternate Fractionation
Part I DISEASE SITE SPECIFIC TOPICS
7 Central Nervous System Cancer
8 Head and Neck Cancer
9 Breast Cancer
10 Lung Cancer
11 Upper Gastrointestinal Cancer: Esophagus and Stomach
12 Upper Gastrointestinal Cancer: Hepatobiliary and Pancreas
13 Lower Gastrointestinal Cancer
14 Genitourinary Cancer
15 Gynecologic Cancer
16 Skin Cancer and Melanoma
17 Sarcoma
18 Lymphoma and Non-Solid Tumors
19 Benign Disease
20 Index.