Follicular dendritic cells (FOe) are unique among cells of the immune system. While their morphological characteristics re sulted in their inclusion as a 'dendritic cell type', tt1ey differ quite significantly from the other members of the dendritic cell family. In contrast to T-cell-associated dendritic cells or the Langerhans cells found in the skin, FOe reside in highly organized B cell follicles within secondary lymphoid tissues. This site of resi dence provided a nomenclature committee in 1982 with the second descriptive factor for the derivation of their name. The cardinal feature of FOe is to trap and retain antigen on the surface of their dendritic processes for extended amounts of time and it is this feature that provides the conceptual compo nent for the title of this book. In response to an antigenic challenge, primary B cell follicles undergo dynamic events, giving rise to germinal centers which are associated with activation, expansion, and differentiation processes of B cells. The interactions of B cells with Foe and T cells in the germinal centers are essential for generating the complete repertoire of antibody isotypes obtained during an antibody response. In addition, stimuli either initiated or main tained during the germinal center reponse leads to production of high affinity antibodies through the processes of somatic muta tion and clonal selection. In this context, FOe act as a pivotal source of antigen. They accumulate foreign proteins (e. g.

List of Contents

A Theory of Follicular Dendritic Cell Origin
Follicular Dendritic Cells: Origin and Function
Mechanism of Immune Complex Trapping by Follicular Dendritic Cells
Follicular Dendritic Cells: Antigen Retention, B Cell Activation, and Cytokine Production
Role of Follicular Dendritic Cells in the Regulation of B Cell Proliferation
Murine Follicular Dendritic Cells: Accessory Activities In Vitro
Regulation of Human B Cell Activation by Follicular Dendritic Cell and T Cell Signals
Follicular Dendritic Cells: Structure as Related to Function
Follicular Dendritic Cells Initiate and Maintain Infection of the Germinal Centers by Human Immunodeficiency Virus
Follicular Dendritic Cells and Infection by Human Immunodeficiency Virus Type 1 - A Crucial Target Cell and Virus Reservoir
Follicular Dendritic Cells in Malignant Lymphomas.