Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.

List of Contents

1. General Aspects
General Physiology and Pathophysiology of the Renin-Angiotensin System
Phylogeny and Ontogeny of the Renin-Angiotensin System
Angiotensin as a Cytokine Implicated in Accelerated Cellular Turnover
Regulation of Angiogenesis by Angiotensin II
Immunohistochemistry of Angiotensin
Renin-Angiotensin System: Plasma Versus Tissues
Angiotensin-Endothelin Interactions
2. Genetics
Genetics of the Human Renin-Angiotensin System
Knockout Models of the Renin-Angiotensin System
Transgenics of the RAS
Gene Therapy and the Renin-Angiotensin System
3. ANG Receptors
AT1
AT1 Receptor Molecular Aspects
AT1 Receptor Interactions
AT1 Receptor Regulation
Angiotensin AT1 Receptor Signal Transduction
Sympathetic Interactions of AT1 Receptors
AT2
Molecular Aspects of AT2 Receptor
AT2 Receptor of Angiotensin II and Cellular Differentiation
AT2 Renal Aspects
AT2 Function and Target Genes
Angiotensin-(1-7). Its Contribution to Arterial Pressure Control Mechanisms
Angiotensin AT4 Receptor.