Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.

List of Contents

4. Tissues
Vascular
Angiotensin II and Oxidative Stress
Angiotensin II and Atherosclerosis
Angiotensin II and Vascular Extracellular Matrix
Renin-Angiotensin Inhibitors and Vascular Effects
Brain/Nervous System
Angiotensin Pathways and Brain Function
Involvement of the Renin Angiotensin System in the Regulation of the Hypothalamic Pituitary Adrenal Axis
Angiotensin Actions on the Brain Influencing Salt and Water Balance
Angiotensin Receptor Signaling in the Brain: Ionic Currents and Neuronal Activity
Angiotensin, Neuroplasticity and Stroke
Heart
Role of Angiotensin II in Cardiac Remodeling
Pathophysiology of Cardiac AT1 and AT2 Receptors
Activation of the Renin-Angiotensin System After Myocardial Infarction
Kidney and Adrenal Gland
Angiotensin II, the Kidney and Hypertension
Angiotensin and Aldosterone Biosynthesis
Aldosterone: Clinical Aspects
5. Inhibition of the Renin-Angiotensin System
ACE Inhibitors
Interactions Between the Renin-Angiotensin and the Kallikrein-Kinin System
ACE Inhibitors: Pharmacology
AT1 Antagonists
AT1 Receptor Antagonists: Pharmacology
Clinical Pharmacology of Angiotensin II Receptor Antagonists
Combined Blockade of the Renin Angiotensin System with ACE Inhibitors and AT1 Receptor Antagonists
NEP/ACE Inhibitors
NEP/ACE Inhibitors: Experimental and Clinical Aspects
6. Clinical Qutlook
Inhibitors of the RAS: Evidence-Based Medicine.