Animal Models of T Cell-Mediated Skin Diseases
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The '50th International Workshop of the Ernst Schering Research Foundation' focussed on 'Animal Models of T Cell-Mediated Skin Diseases'. Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
1;Preface;5 2;Contents;7 3;List of Editors and Contriiutors;9 4;1 Making Gene-Modified Mice;14 5;2 High-Throughput Gene Knockouts and Phenottping in Mice;40 6;3 Modelling Gene-Environment Interactions in Th1-and Th2-Dominated Diseases of Laboratory Animals;58 7;4 AnimalModels of Experimental Asthma;82 8;5 Models of Rheumatoid Arthritis;101 9;6 Animal Models of Inflammatort Bowel Diseases;130 10;7 Murine Models of Atopic Dermatitis;144 11;8 Epicutaneous Sensitiiation with Allergens as an Atopic Dermatitis Model;178 12;9 T-Cell Receptor Transgenic Models of Inflammatort Disorders: Relevance for Atopic Dermatitis?;186 13;10 What Must a Model Display for Proof as a Modelof Psoriasis?;203 14;11 From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice;212 15;12 The Psoriasis SCID Mouse Model: A Toolfor Drug Discovert?;222 16;13 Pro-and Anti-inflammatort Effects of IL-4: From Studies in Mice to Therapy of Autoimmune Diseases in Humans;244 17;14 What Must a Model Display for Proof as a Modelof Contact Dermatitis?;252 18;15 Acute and Chronic Models of Allergic Contact Dermatitis: Advantages and Limitations;263 19;16 Transgenic Mice Expressing IFN-y in the Epidermis Are a Model of Inflammatory Skin Disease and Ststemic Lupus Ertthematosus;284
Zollner, T.
Renz, H.
Asadullah, K.
| ISBN | 9783540268116 |
|---|---|
| Artikelnummer | 9783540268116 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2007 |
| Verlag | Springer-Verlag |
| Umfang | 291 Seiten |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
