This volume reviews the known neurobiology of depression and combines classic data on antidepressant treatments with modern theory on the physiology of depression. It also discusses novel mechanism of action drugs.

Part 1:  Overview and General Principles

1. Impact, Diagnosis, Phenomenology, and Biology
Part 2:  The Past - from antiquity to 1970 including TCAs and MAOIs
2. Tricyclic Antidepressants and Monoamine Oxidase Inhibitors: Are They Too Old for a New Look?
Part 3:  The Present- 1970 to 2016
3. Clinical Implications of the STAR*D Trial
4. Pharmacogenomics and Biomarkers of Depression
5. Therapeutic Drug Monitoring of Antidepressants
6. Selective Serotonin Reuptake Inhibitors
7. Serotonin and Norepinephrine Reuptake Inhibitors
8. Neurostimulation Therapies
9. Current Role of Herbal and Natural Preparations
Part 4: The future
10. Role of Inflammation in Depression and Treatment Implications
11. NMDA Antagonists for Treatment-Resistant  Depression
12. Drug Development in Psychiatry: The Long and Winding Road from Chance Discovery to Rational Development
13. Other Antidepressants
Part 5: Use of Antidepressants in Special Populations
14. Use of Antidepressants in Patients with Co-occurring Depression and Substance Use Disorders
15. Treatment of Depression in Women
16. Management of Late-Life Depression
17. The Use of Antidepressants in Bipolar Depression.