The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.

Learning and Memory

Animal Models of Anxiety
Genetic Alterations of the Murine Serotonergic Gene Pathway: The Neurodevelopmental Basis of Anxiety
Mutagenesis and Knockout Models: Hypothalamic-Pituitary-Adrenocortical System
Mutagenesis and Knockout Models: NK1 and Substance P
Genetic Epidemiology of Anxiety Disorders
Interactions Between Corticotropin-Releasing Hormone and Serotonin: Implications for the Aetiology and Treatment of Anxiety Disorders
Anxiety Disorders: Noradrenergic Neurotransmission
Pathophysiology and Pharmacology of GABAA Receptors
Excitatory Amino Acid Neurotransmission
Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity
Neuropeptides in Anxiety Modulation
Neuroendocrine Aspects of PTSD
Anxiety Disorders: Clinical Presentation and Epidemiology
Transcultural Issues
Challenge Studies in Anxiety Disorders
Pharmacotherapy of Anxiety
New Pharmacological Treatment Approaches for Anxiety Disorders
Pharmacogenomics
Pharmacoproteomics.