Physicians, biologists and physicists present their recent work in the field of hyperthermia with regard to both its application and its combination with radiation and chemotherapy. Current technical possibilities, clinical management and major aspects of its use for superficial and deep-seated tumors are pointed out. The main topics discussed are: changes of metabolism and microcirculation under heat conditions, the biological interaction of heat with X-rays and several chemotherapeutic agents, and the most recent clinical data from different institutions on the combined application in the treatment of cancer.

Biological, Biophysical and Technical Concepts of Hyperthermia

The Concept of Thermal Dose
Aspects of Metabolic Change After Hyperthermia
Hyaluronic Acid Degradation Mediated by Thiols and Effects of Hyperthermic Conditions
Glutathione Level in Melanoma Cells and Tissue
Changes of Plasma Acetate Levels in Whole-Body Hyperthermia
Physiological Effects of Hyperthermia
Hyperthermia-Induced Changes in Tumor Microcirculation
Changes in Tumor Vasculature Under Fractionated Radiation -Hyperthermia Treatment
Pathophysiology of Tumors in Hyperthermia
Technical Aspects of Hyperthermia
Advanced Technique in Localized Current Field Hyperthermia
A 500-kHz Localized Current Field Hyperthermia System for Use with Ophthalmic Plaque Radiotherapy
Simulation of Interstitial Microwave Hyperthermia Using the Finite Element Method
Hyperthermia and Radiation:Biological and Clinical Studies
Some Basic Effects in Cellular Thermobiology
Growth, Cell Proliferation and Morphological Alterations of a Mouse Mammary Carcinoma After Exposure to X-Rays and Hyperthermia
Analysis of Results in Neck Node Metastases from Tumors of the Head and Neck
Two Versus Six Hyperthermia Treatments in Combination with Radical Irradiation for Fixed Metastatic Neck Nodes: Progress Report
First Results After Hyperthermia Treatment with the BSD System in Essen
Interstitial Radiotherapy Combined with Interstitial Hyperthermia in the Management of Recurrent Tumors
Localized, Non-Invasive Deep Microwave Hyperthermia for the Treatment of Prostatic Tumors: The First 5 Years
External Microwave Hyperthermia Combined with Radiation Therapy for Extensive Superficial Chest Wall Recurrences
Microwave-Induced Hyperthermia and Radiotherapy in Human Superficial Tumors: Clinical Results witha Comparative Study of Combined Treatment Versus Radiotherapy Alone
Hyperthermia and Chemotherapy: Biological and Clinical Studies
Interaction of Hyperthermia and Chemotherapy
Thermostability of Cytostatic Drugs in Vitro and Thermosensitivity of Cultured Human Lymphoblasts Against Cytostatic Drugs
A Rapid in Vitro Assay for PredictingThermochemosensitivity of Human Cancer:Comparison with Clonogenic Assay
The Cytotoxic and Bleomycin-Sensitizing Effect of Hyperthermia on Different Cell Lines
Pilot Studies of Microwave-Induced Brain Hyperthermia and Systemic BCNU in a Rat Glioblastoma Model
Pharmacokinetics of Methotrexate During Regional Hyperthermia in a Pig Model
Summary of Recent Clinical Experience in Whole-Body Hyperthermia Combined with Chemotherapy
Coagulation and Fibrinogenolysis During Whole-Body Hyperthermia
Treatment of Superficial Neoplastic Lesions Using Hyperthermia, Radiotherapy, and Chemotherapy
Clinical Experience in the Combination of Hyperthermia with Chemotherapy or Radiotherapy
Combined Treatment of Advanced Bladder Carcinoma
Experience with an Annular Phased Array Hyperthermia System in the Treatment of Advanced Recurrences of the Pelvis
Regional Hyperthermia Combined with Systemic Chemotherapy in Advanced Abdominal and Pelvic Tumors: First Results of a Pilot Study Employing an Annular Phased Array Applicator
Deep Microwave Hyperthermia for Metastatic Tumors of the Liver
Future Trends in Heating Technology of Deep-Seated Tumors
Percutaneous Placement of Catheters for Temperature Measurement During Hyperthermia
CT-Guided Placement of Temperature Probes in Pulmonary Cancer.