This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors

Arrestin-biased GPCR Agonists
Arrestin-1 Expression Levels, Rod Function and Health
Protective Functions of Arrestin-1 in Photoreceptors
Arrestin-4 and Cone Function
Enhanced Phosphorylation-independent Arrestins and Gene Therapy
Targeting Particular Receptors with Redesigned Non-visual Arrestins
Arrestins binding to clathrin, AP2 and Role in GPCR trafficking
Arrestins in Ubiquitination and Deubiquitination
Arrestin Self-association
Arrestin-dependent Activation of ERK and Src
Arrestin-dependent Activation of JNK Family Kinases
Arrestin-Mediated P38 Activation
Arrestin-dependent PDE Localization
Arrestins in Cell Migration
Arrestins in Host-pathogen Interactions
Arrestin Regulation of Small GTPases
GPCRs and Arrestins in Airways: Implications for Asthma
Arrestins as Regulatory Signaling Hubs in Cancer Pathways
Arrestins in Pain and Anesthesia.