1;Preface;5 2;List of Contents;7 3;List of Contributors;10 4;Background;12 4.1;The Pathogenesis of Atherosclerosis;13 4.2;Risk Factors for Atherosclerotic Vascular Disease;81 4.3;Metabolic Syndrome: Therapeutic Considerations;116 5;The Impact of Diet;143 5.1;Physical Activity, Obesity and Cardiovascular Diseases;144 5.2;Fatty Acids and Atherosclerotic Risk;171 5.3;Dietary Cholesterol, Atherosclerosis and Coronary Heart Disease;201 5.4;Plant Sterols and Stanols;220 5.5;Carbohydrates and Dietary Fiber;236 5.6;Dietary Antioxidants and Paraoxonases Against LDL Oxidation and Atherosclerosis Development;267 5.7;Soy, Isoflavones and Atherosclerosis;305 5.8;Homocysteine and B Vitamins;328 5.9;Alcohol;342 6;Evidence-Based Anti-Atherosclerotic Drug Therapy;365 6.1;Lipid and Non-lipid Effects of Statins;366 6.2;Fibrates;390 6.3;ACE Inhibitors and Angiotensin II Receptor Antagonists;408 6.4;Inhibition of Platelet Activation and Aggregation;444 7;Targets of Future Anti-Atherosclerotic Drug Therapy;464 7.1;The ABC of Hepatic and Intestinal Cholesterol Transport;465 7.2;Inhibition of the Synthesis of Apolipoprotein B-Containing Lipoproteins;483 7.3;Therapy of Hyper-Lp(a);518 7.4;Modulation of High-Density Lipoprotein Cholesterol Metabolism and Reverse Cholesterol Transport;536 7.5;Inhibition of Lipoprotein Lipid Oxidation;561 7.6;Correction of Insulin Resistance and the Metabolic Syndrome;589 7.7;Protection of Endothelial Function;616 7.8;Modulation of Smooth Muscle Cell Proliferation and Migration: Role of Smooth Muscle Cell Heterogeneity;642 7.9;Modulation of Macrophage Function and Metabolism;661 7.10;Inflammation Is a Crucial Feature of Atherosclerosis and a Potential Target to Reduce Cardiovascular Events;692 7.11;Autoimmune Mechanisms of Atherosclerosis;718 7.12;Drug Therapies to Prevent Coronary Plaque Rupture and Erosion: Present and Future;739 7.13;Reciprocal Role of Vasculogenic Factors and Progenitor Cells in Atherogenesis;771 7.14;Gene Therapy of Atherosclerosis;778 8;Subject Index;801