Azaheterocycles Based on a,ß-Unsaturated Carbonyls
This monograph is devoted to heterocyclization of aliphatic and aromatic a,ß-unsaturated carbonyls with various binucleophiles. These reactions produce partially hydrogenated nitrogen-containing heterocycles that are interesting due to their significant role in biological processes. They can be used in conjunction with combinatorial high throughput methods that involve microwave-assisted and ultrasonic-promoted reactions. The monograph is a comprehensive review of the known literature data devoted to the reactions of a,ß-unsaturated ketones, their synthetic equivalents and precursor. It is intended for chemists working in the field of experimental syntheses and theoretical investigations of nitrogen-containing heterocycles, lecturers at university and graduate students.
1;Preface;5 2;Contents;7 3;Introduction;8 3.1;References;10 4;Three-Membered Azaheterocycles;12 4.1;1.1 Synthesis of Aziridinyl Ketones and Their Chemical Properties;12 4.2;1.2 Synthesis of Bi- and Tricyclic Aziridine Derivatives;22 4.3;1.3 Chemical Properties of Bi- and Tricyclic Aziridines;27 4.4;References;40 5;Five-Membered Azaheterocycles;44 5.1;2.1 Reactions with Diazoalkanes;44 5.2;2.2 Reactions of Hydrazines and Hydroxylamines;48 5.3;2.3 Structure, Chemical and Physicochemical Properties of Pyrazolines;57 5.4;References;62 6;Six-Membered Azaheterocycles Based on 1,3- Binucleophiles;68 6.1;3.1 Reactions of Enamines;69 6.2;3.2 Reactions of Urea and Its Analogues;72 6.3;3.3 Reactions of Malonic Acid Derivatives;83 6.4;3.4 Reactions of Aminoazoles;90 6.5;3.5 Reactions of Anilines and Aminoazines;107 6.6;3.6 Chemical Properties of Dihydroazines;115 6.7;3.7 Tautomerism of Pyridine and Pyrimidine Dihydro Derivatives;137 6.8;References;143 7;Cyclocondensations of 1,2-Diamines;155 7.1;4.1 Synthesis of 1,5-Dihydroazepines;155 7.2;4.2 Three-Component Condensation of 1,2-Diamines with Ketones;163 7.3;4.3 Reactions of Dihydrobenzodiazepines;169 7.4;4.4 Five- and Six-Membered Heterocycles Based on ortho- Diamines;176 7.5;References;182 8;Addendum: Selected Synthetic Procedures;187 8.1;A.1 Synthesis of Three-Membered Heterocycles ;187 8.2;A.2 Synthesis of Five-Membered Heterocycles ;193 8.3;A.3 Synthesis of Six-Membered Heterocycles ;197 8.4;A.4 Reactions of a,b- Unsaturated Carbonyls with 1,2- Diamines ;205 8.5;References;208 9;Index;210
Chebanov, Valentin A.
Desenko, Sergey M.
Gurley, Thomas W.
| ISBN | 9783540683674 |
|---|---|
| Artikelnummer | 9783540683674 |
| Medientyp | E-Book - PDF |
| Copyrightjahr | 2008 |
| Verlag | Springer-Verlag |
| Umfang | 210 Seiten |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
