Bacteriophages as Drivers of Evolution

An Evolutionary Ecological Perspective

Bacteriophages as Drivers of Evolution

An Evolutionary Ecological Perspective

149,79 €*

in Vorbereitung

This monograph emphasizes the many facets of bacterial evolution as impacted by bacterial interactions with phages, as well as, to a lesser degree, the evolutionary impact of phages on other organisms, including other phages. 

The book starts with a general overview of bacteriophages. Topics discussed in detail include but are not limited to mutagenesis, migration, natural selection and genetic drift as the drivers of evolution as well as an extensive discussion from the author's unique perspective on phage ecology. 



<p><b>Part I.                  </b><b>Introductions</b></p>1         Bacteriophages, a Brief Introduction<p></p><p>                                                                                  1.1      Introduction to Phages and Their Biology</p>                                                                                  1.2      Most Phages Lyse Their Hosts to Release Virion Progeny<p></p><p>                                                                                  1.3      Some Variations on the Concept of Lysogeny</p><p>                                                                                  1.4      Phage Infections Start with Adsorption</p><p>                                                                                  1.5      Some Phages Can Transport Bacterial DNA between Bacteria via Transduction</p><p>References</p><p>2         A Closer Overview of Phage Infections</p><p>                                                                                  2.1      Lytic Cycles Kill Bacteria but also Produce New Phage Virions</p><p>                                                                                  2.2      Some Vagaries of Lysogenic Cycles</p><p>                                                                                  2.3      Looking at Lysogenic Cycles from Ecological Perspectives</p><p>                                                                                  2.4      Looking at Lysogenic Cycles from Evolutionary Perspectives</p><p>                                                                                  2.5      Chronic Cycles Release New Phage Virions without Killing Host Bacteria</p><p>References</p><p>3         Evolution Biology Basics</p><p>                                                                                  3.1      Introduction to Evolution</p><p>                                                                                  3.2      The No-Evolution Default Assumption</p><p>                                                                                  3.3      Natural Selection and Darwinian Fitness: Relative and Absolute</p><p>References</p><p>4         Brief Introduction to Phage Ecology</p><p>                                                                                  4.1      Phage Organismal Ecology</p><p>                                                                                  4.2      Phage Population Ecology</p><p>                                                                                  4.3      Phage Community Ecology</p><p>                                                                                  4.4      Prophages Are at the Interface of Phage Population and Community Ecologies</p>                                                                                  4.5      Mobile Genetic Elements Parasitizing Phages<p></p><p>References</p><p><b>Part II.                </b><b>Mutation, Genetic Drift, and Non-Random Mating</b></p><p>5         Bacterial Mutation Associated with Phages: Insertion</p><p>                                                                                  5.1      Mutations, Mutants, Mutagenesis</p><p>                                                                                  5.2      Secondary Insertion Sites</p><p>                                                                                  5.3      For Phage Mu, Insertional Mutagenesis Is a Key Aspect of Its Infection Cycle</p><p>                                                                                  5.4      CRISPR Spacer Sequences Are and Are Not Insertion Mutations</p><p>References</p><p>6         Bacterial Mutation Associated with Phages: Deletions</p><p>                                                                                  6.1      Pseudogenes</p><p>                                                                                  6.2      Genomic Immunity against Prophages?</p><p>                                                                                  6.3      Evidence for the Existence of Genomic Immunity?</p><p>                                                                                  6.4      Just How Dangerous are Prophages?</p>                                                                                  6.5      Just How Dangerous Are Pseudogenes?<p></p><p>                                                                                  6.6      Bacterial Chromosomal Rearrangements and Prophages</p><p>References</p><p>7         Genetic Drift and Phages</p><p>                                                                                  7.1      Stochasticism versus Determinism</p><p>                                                                                  7.2      Sampling Error</p><p>                                                                                  7.3      Reduction of Bacterial Population Size: Genetic Bottlenecking</p><p>                                                                                  7.4      Potential Impact of Spatial Structure: Founder Effects</p><p>References</p><p>8         Phages and sexual Bacterial Populations</p><p>                                                                                  8.1      Introducing Some Natural Selection: Genetic Hitchhiking</p><p>                                                                                  8.2      Muller's Ratchet</p><p>References</p><p>9         Phage Impact on Non-Random Mating Among Bacteria</p><p>                                                                                  9.1      Transduction and Panmixis</p><p>                                                                                  9.2      Various Limitations on Random Mating</p><p>                                                                                  9.3      Bacterial Retention of Transduced DNA</p><p>                                                                                  9.4      What Happens If There Is No Horizontal Gene Transfer within Populations?</p><p>References</p><p><b>Part III.              </b><b>Genetic Migration</b></p>10     Genetic Migration and Phages<p></p><p>                                                                              10.1      Phage-Mediated Introduction of New Alleles into Bacterial Populations</p><p>                                                                              10.2      Assortative Mating Introduced by Phages</p><p>                                                                              10.3      Reciprocal versus Non-reciprocal Transduction</p><p>                                                                              10.4      Direct and Indirect Reciprocal Transduction</p><p>                                                                              10.5      Stabilizing versus Disruptive Transduction</p><p>References</p><p>11     Reproductive Isolation and Its Violation by Phages</p><p>                                                                              11.1      Barriers to Transduction as Defining Bacterial Species?</p><p>                                                                              11.2      Zones of Paralogy</p><p>                                                                              11.3      All the World's a Phage</p><p>                                                                              11.4      Moron Accretion</p><p>References</p><p>12     Phage-Provided Environmental DNA and Superspreading</p><p>                                                                              12.1      Uptake of Naked DNA</p><p>                                                                              12.2      Phage-Generation of eDNA</p><p>                                                                              12.3      Phages as Mediators of 'Superspreading'</p><p>                                                                              12.4      Temperate Phages as Generators of eDNA</p><p>References</p><p>13     Transduction of Large Amounts of DNA</p><p>                                                                              13.1      Generalized Transduction</p><p>                                                                              13.2      Homologous Recombination versus Illegitimate Recombination</p><p>                                                                              13.3      Genomic Islands</p><p>References</p><p><b>Part IV.             </b><b>Prophage-Encoding of Bacterium-Expressed Genes</b></p><p>14     Phage Morons</p><p>                                                                              14.1      What Is a Moron? (Narrow Sense)</p><p>                                                                              14.2      What Isn't a Moron? (Narrow Sense)</p><p>                                                                              14.3      Limitations on Phage Acquisition of Additional Genes</p><p>                                                                              14.4      Morons as Lysogenic Converting Genes</p><p>References</p><p>15     Why Lysogenic Conversion?</p><p>                                                                              15.1      More than Lytic Cycle Buttressing of Accessory Gene Encoding?</p><p>                                                                              15.2      A Plethora of Possible Selective Mechanisms</p><p>                                                                              15.3      Indirect Selection for Lysogenic Conversion</p><p>                                                                              15.4      Direct selection for Lysogenic Conversion</p>                                                                              15.5      Lysogenic Conversion and Ecotypes<p></p><p>                                                                              15.6      Phage-Encoded Phage Resistance</p><p>References</p><p>16     Prophages Preventing Phage Superinfection</p><p>                                                                              16.1      Superinfection Immunity</p><p>                                                                              16.2      Superinfection Exclusion</p><p>                                                                              16.3      Prophage Encoding of Other Phage-Resistance Mechanisms</p><p>References</p><p>17     Domestication of Phage Genes</p><p>                                                                              17.1      Merging of Genomes</p><p>                                                                              17.2      Merging of Phage Genomes</p><p>                                                                              17.3      Merging of Phage and Bacterial Genomes</p><p>                                                                              17.4      Phage Gene Domestication without Prophage Integration</p><p>                                                                              17.5      Getting Rid of Plasmid Prophage Genes?</p><p>References</p><p><b>Part V.               </b><b>Phage Resistance</b></p>18     Resistance to Phages, Part I: Overview<p></p><p>                                                                              18.1      Categorizing Phage-Resistance by Outcomes</p><p>                                                                              18.2      Avoidance of Phage Infection</p><p>                                                                              18.3      Negation of Phage Infections</p><p>                                                                              18.4      Bacterial Self-Sacrifice upon Phage Infection</p><p>                                                                              18.5      Delay of Phage Propagation</p><p>                                                                              18.6      Summary</p><p>References</p><p>19     Resistance to Phages, Part II: Bacteria Live!</p><p>                                                                              19.1      Avoidance of Phage Genome Uptake</p><p>                                                                              19.2      Negating Phage Infections Soon after Initiation</p><p>References</p><p>20     Resistance to Phages, Part III: Bacteria Die...</p><p>                                                                              20.1      The Bacterial Self-Sacrifice of Abortive Infections</p><p>                                                                              20.2      Delay: Slowing Down Phage Population Growth </p><p>References</p><p>21     Bacterial Mutation to Phage Resistance</p><p>                                                                              21.1      A Plethora of Possible Targets of Mutation?</p><p>                                                                              21.2      Rates of Mutation to Resistance</p><p>                                                                              21.3      A Wee Bit of Advice</p><p>References</p>22     Pleiotropic Costs of Phage Resistance<p></p><p>                                                                              22.1      Antagonistic Pleiotropies</p><p>                                                                              22.2      Some History</p>                                                                              22.3      A Sampling of More Modern Studies<p></p><p>References</p><p><b>Part VI.             </b><b>Natural Selection</b></p><p>23     Concepts of Natural Selection in Light of Phage Exposure</p><p>                                                                              23.1      Higher Fitness</p><p>                                                                              23.2      Beneficial Alleles and Adaptation</p><p>                                                                              23.3      Historical Contingencies</p><p>                                                                              23.4      Hard Selection and Soft Selection</p><p>                                                                              23.5      Coevolution</p><p>References</p><p>24     Frequency-Dependent Selection in Light of Phage Exposure</p><p>                                                                              24.1      Ecological versus Evolutionary: Three Distinctions</p><p>                                                                              24.2      Stabilizing, Disruptive, Polymorphic, Monomorphic</p><p>                                                                              24.3      Disruptive Frequency-Dependent Selection-Extracellular Toxins</p><p>                                                                              24.4      Disruptive Frequency-Dependent Selection-Induced Prophages</p>                                                                              24.5      Frequency Dependence or Instead Density Dependence?<p></p><p>                                                                              24.6      Stabilizing Frequency-Dependent Selection Involving Phages</p><p>                                                                              24.7      Killing the Winner</p><p>                                                                              24.8      Stabilizing Frequency-Dependent Selection Mimicking Muller's ratchet?</p><p>References</p><p>25     A Primer on Phage-Bacterium Antagonistic Coevolution</p><p>                                                                              25.1      Preamble</p><p>                                                                              25.2      Introduction to Coevolution and Antagonistic Coevolution</p><p>                                                                              25.3      Short Historical Overview of Phage-Bacterium Antagonistic Coevolution</p><p>                                                                              25.4      Brief Primer on Phage-Bacterium Antagonistic Coevolution</p>                                                                              25.5      Different Faces of Phage-Bacterium Antagonistic Coevolution<p></p><p>                                                                              25.6      An Indefinite Series of Coevolutionary Change?</p><p>                                                                              25.7      Coda</p><p>References</p>
ISBN 978-3-030-94308-0
Artikelnummer 9783030943080
Medientyp Buch
Auflage 1st ed. 2022
Copyrightjahr 2022
Verlag Springer, Berlin
Umfang XXV, 377 Seiten
Abbildungen XXV, 377 p. 1 illus.
Sprache Englisch