A century ago the Italian pathologist Bizzozero described the relationships between spiral bacteria and the mammalian gastro intestinal tract. Since 1982, when Helicobacter pylori was discovered, gastroduodenal disease have been completely revised as a con sequence of the results of basic and clinical research in this field. Progress in understanding the pathogenesis of this bacterium has been made by studying H. pylori infection in animal models. More specific diagnostic tools have been developed using new molecular biology techniques. Future trends are directed towards preparing a specific H. pylori vaccine. A new classification for gastritis, the Sydney System, including H. pylori gastritis, was proposed in 1990. As concerns the clinical approach to peptic ulcer disease in the 1990's, the majority of authors agree on the importance of H. pylori eradication. Moreover, recent clinical studies suggest that H. pylori infection can be associated with other gastroduodenal diseases, such as non ulcer dyspepsia and gastric cancer. Multicenter trials to standardize serological methods and evaluate the efficacy of new antimicrobial therapy schedules are planned throughout different European countries. The fourth Workshop of the European Helicobacter Pylori Study Group was held in Bologna, Italy, in November 1991. Two years before Bologna University celebrated its ninth centennial, giving evidence of being the oldest University in the modern world. Thus the H. pylori story that has continued for more than a century has been discussed once again at the University with the oldest tradition in the world.

Nonulcer Dyspepsia

Nonulcer Dyspepsia
Nonulcer Dyspepsia: Psychological Considerations
Nonulcer Dyspepsia and Helicobacter pylori: Effect of Eradication on Symptoms and Gastritis
Upper Gastrointestinal Endoscopy and the Prevalence of Helicobacter pylori Infection in Recurrent Abdominal Pain of Childhood
The Value of Serodiagnosis of Helicobacter pylori in Predicting Negative Gastroscopy
The Icelandic Nonulcer Dyspepsia/Helicobacter pylori Study: Symptomatic Response and Eradication Rate with De-Nol or De-Nol Plus Metronidazol in Treatment of Helicobacter-Positive Patients with Nonulcer Dyspepsia
Long-Term Follow-up of Children with Helicobacter pylori-Associated Nonulcer Dyspepsia After Eradication of the Infection
Helicobacter pylori, Surgery, and Aging
The Role of Ulcer Surgery Today
Effect of Single-Shot Antibiotic Treatment on Helicobacter pylori in Patients Undergoing Ulcer Operation
The Aging Stomach
Pathogenic Mechanisms of Helcobacter pylori Infection: Virulence
Construction of a Molecular Population GeneticFramework for the Characterization ofHelicobacter pylori Pathogenesis by Multilocus Enzyme Electrophoresis
The Flagella of Helicobacter pylori: Molecular Analysis and Potential in Pathogenesis
Identification of Potential S Layer Proteins of Helicobacter pylori
Urease as a Colonisation Factor in Helicobacter
Affinity and Ion Exchange Chromatography in the Purification and Characterization ofHelicobacter pylori Cytotoxin-Associated Proteins
Neutralization of the Vacuolating Toxin from Helicobacter pylori by Antisera from Patients with Duodenal or Gastric Ulcer
Helicobacter pylori: PhosphoHpase C and Haemolysis
Haemaglutinins ofHelicobacter pylori and Adherence to HEp-2 Cells
Partial Purification and Characterization ofSialic Acid Specific Soluble Haemagglutinin(s) of Helicobacter pylori Strain NCTC 11637
Pathogenic Mechanisms of Helicobacter pylori Infection: Host Response
The Role of Helicobacter pylori Gastritis in Ulcerogenesis and Carcinogenesis
Isolation and Phenotypical Characterization of T-Lymphocytes Isolated from the Gastric Mucosa of Patients With and Without Helicobacter pylori
Demonstration of the Major Cytotoxin-Association Protein of Helicobacter pylori in Gastric Biopsies by Western Blotting
Gastric Functions and Helicobacter pylori Infection in Patients with Fundic Atrophic Gastritis
Peptic Ulcer in the Elderly: Not a Helicobacter-RelatedCondition?
Serology of Helicobacter pylori Infection
The Use of Helicobacter pylori Serology in Diagnosis and Treatment Monitoring
The Use of Serological Detection of Helicobacter pylori in Epidemiology
Helicobacter pylori Serology: Kit Evaluation and Comparison
Standards for Serologic Study of Infection with Helicobacter pylori
Helicobacter pylori Antigenic Preparations
The Value of Class and Subclass ELISAs and Antibody Specificity in Monitoring Treatment of Helicobacter pylori
Future Prospects for Helicobacter pylori Serology
TheHelicobacter pylori San Marinq Study: Seroepidemiology of Helicobacter pylori Infection in the Republic of San Marino
Molecular Biology of Helicobacter pylori
Construction of Isogenic Mutants of Helicobacter pylori Deficient in Urease Activity
Cloning of a Helicobacter pylori Flagellin Gene and Construction of a Nonflagellated Mutant by Transformation-Mediated Allelic Exchange
Identification and Characterization of an Adhesion Gene of Helicobacter pylori by Cloning
Molecular Cloning and Nucleotide Sequence Determination of htrA, a Gene Encoding a 48-kDa Stress Protein of Helicobacter pylori
Diagnosis of Helicobacter pylori in Gastric Juice Aspirates Using Polymerase Chain Reaction
Molecular Fingerprinting of Helicobacter pylori: An Evaluation of Methods
Developments in Ribotyping of Helicobacter pylori
The 130-kDa Vacuolating Cytotoxin-Associated Protein Is a Component of Cytotoxic Helicobacter pylori Organisms
The Cloning and Partial Sequence Analysis of the Catalase Gene of Helicobacter pylori
Binding of Helicobacter pylori to Extracellular Matrix Proteins
Therapeutic Approaches
Helicobacter pylori: Clinical Aspects
H2 Receptor Antagonists: Is There a Place in the Treatment of Helicobacter pylori Infection?
Proton Pump Inhibitors in the Management of Helicobacter pylori-Related Diseases
Pharmacology of Bismuth-Containing Medicines Used to Treat Helicobacter pylori Infections
Bismuth and Helicobacter pylori
Antibiotics in Helicobacter pylori Treatment
Clinical Application of Antibiotics in Eradicating Helicobacter pylori
Cytoprotective Drugs and Helicobacter pylori Infection
Approaches to the Treatment of Helicobacter pylori Infection.