Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease
Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease
Motor dysfunction and cognitive impairment are major symptoms in both Huntington's Disease (HD) and Parkinson's Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Neurobiology of Huntington's Disease
Mouse Models of Huntington's Disease
Transgenic Rat Models of Huntington's Disease
Large Animal Models of Huntington's Disease
Therapeutic Strategies for Huntington's Disease
Clinical and Pathological Features of Parkinson's Disease
Symptomatic Models of Parkinson's Disease and L-DOPA-Induced Dyskinesia in Non-human Primates
Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?
Viral Vector-Based Models of Parkinson's Disease
Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits
Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents
Models of Multiple System Atrophy.<br />
Clinical Aspects of Huntington's Disease
The Neuropathology of Huntington's DiseaseNeurobiology of Huntington's Disease
Mouse Models of Huntington's Disease
Transgenic Rat Models of Huntington's Disease
Large Animal Models of Huntington's Disease
Therapeutic Strategies for Huntington's Disease
Clinical and Pathological Features of Parkinson's Disease
Symptomatic Models of Parkinson's Disease and L-DOPA-Induced Dyskinesia in Non-human Primates
Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?
Viral Vector-Based Models of Parkinson's Disease
Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits
Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents
Models of Multiple System Atrophy.<br />
Nguyen, Hoa Huu Phuc
Cenci, M. Angela
ISBN | 978-3-662-46343-7 |
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Artikelnummer | 9783662463437 |
Medientyp | Buch |
Copyrightjahr | 2015 |
Verlag | Springer, Berlin |
Umfang | XIII, 397 Seiten |
Abbildungen | XIII, 397 p. 95 illus., 25 illus. in color. |
Sprache | Englisch |