The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.

A Review of the Cholinergic System and Therapeutic Approachesto Treat Brain Disorders

Acetylcholine and Spontaneous Recognition Memory in Rodentsand Primates
Endogenous Acetylcholine and Its Modulation of Cortical Microcircuitsto Enhance Cognition
Cholinergic Signaling Dynamics and Cognitive Control of Attention
Involvement of Nicotinic Receptors in Working Memory Function
Nicotinic Receptors Underlying Nicotine Dependence: Evidence fromTransgenic Mouse Models
Cholinergic Receptors and Addiction
Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine Receptors
An Evolving Therapeutic Rationale for Targeting the 7 Nicotinic Acetylcholine Receptor in Autism Spectrum Disorder
Activators of 7 nAChR as Potential Therapeutics for Cognitive Impairment.