" ... this is an excellent compilation of data which should be on the bookshelves of all analysts interested in the benzodiazepines. It is to be hoped that, with the introduction of so many new ben zodiazepines, the author will quickly add these in a second edi tion" (A. C. Moffat in: Trends in Analytical Chemistry, 1983). This review, deputizing for many others, reflects the friendly reception enjoyed by the first volume of Benzodiazepines, which was published in 1982 and apparently closed a gap in the ben zodiazepine literature. In the meantime, Benzodiazepines has established itself as a standard book, as evidenced by numerous letters and quotations. Suggestions were also soon made for a new edition in view of the unusually rapid development in the field of the benzodiazepines. It became quickly obvious, however, that it would not be sufficient to publish a revised second edition, but that a completely new second volume would be required for which, however, the successful previous format could be largely retained. The following considerations seem worth mentioning in connection with the preparation of Volume II: - To ensure continuity with Volume I as far as possible, the list of references was consecutively numbered (references 1 to 3779 in Volume I, references 3780 to 11338 in Volume II). Whereas in Vol. I the substances appear in the sequential order of their historical development they are listed in alphabetical order in Vol. II.

Index of Treated Substances

List of Synonyma
Biotransformation
Formation of the Hydrolysis Derivatives
TLC-Data
Thin-Layer Chromatography - The Concept of the Corrected Rf-Value (Rfc-Value)
Screening of the Benzodiazepines via Rfc-Values
Screening of the Benzodiazepines via Aminobenzophenones and Bratton-Marshall Detection
GLC-Data and UV-Spectra
Gas Chromatography - The Concept of the Retention Index
List of UV-Maxima
UV-Spectra (Ultraviolet-Spectra)
List of Important m/z-Values
Infrared- and Mass-Spectra
Immunological Methods
Presentation of Analytical Methods
Methods for the Determination of New Benzodiazepines
Additional Methods for the Determination of Benzodiazepines Already Described in Vol. I
List of Therapeutic and Toxic Concentrations
Blood-, Serum- and Plasma-Levels and Other Pharmacokinetic Data from Literature
alprazolam
brotizolam
clotiazepam
delorazepam, chlordesmethyldiazepam
estazolam
ethyl loflazepate
flumazenil, Ro 15-1788
halazepam
loprazolam
metaclazepam
midazolam
oxazolam
pinazepam
quazepam
temazepam
tetrazepam
triazolam
Survey of Benzodiazepine Literature
1 Absorption Studies
2 Analytical Studies
3 Antagonist Studies
4 Anesthesia Studies
5 Behavioral Studies
6 Biotransformation/Metabolism
7 Casuistics
8 Feto-Maternal-Studies
9 GABA-Studies
10 Galenic Studies
11 Gas-Chromatography
12 High-Pressure-Liquid-Chromatography
13 Hydrolysis Studies
14 Immunoassays (RIA, EMIT, TDx and Others)
15 Interactions
16 Mass-Spectrometry
17 NMR-Studies
18 Pharmacokinetics (Levels)
19 Pharmacology and Clinical Studies
20 Photometry (UV-, IR-, VIS-, Fluorometry)
21 Polarography
22 Protein Binding
23 Radioactive-Labelled Compounds
24Radioreceptor Assays
25 Receptor Studies
26 Review Articles
27 Screening Methods
28 Side-, Adverse-, Residual-Effects
29 Sleep Studies
30 Synthesis of Benzodiazepines
31 TLC-Studies
32 Toxicity
33 Miscellaneous
References.