In conjunction with the Twelfth International Congress of Gerontology, the Carl-Korth Institute for Cardiovascular Research organized an international symposium on "Beta Blockers in the Elderly." It was the intention of the Scientific Committee that during this symposium we would discuss the specific problems and therapeutic implications arising when elderly people have to be treated with beta-blocking agents. Special emphasis was placed on the side effects and the age dependent features of beta-blocker therapy. Beta-blockers have become established in the treatment of both cardiovascular diseases and neuropsychiatric disorders. Their effectiveness in patients suffering from coronary heart disease, hypertension, and hyperkinetic cardiac syndromes has long been proven. The development of new, selectively active beta-blockers has substantially reduced the number of possible side effects, thus enhancing therapeutic safety. Because side effects cannot be eliminated, however, beta blockers have been introduced only hesitantly into treatment of the elderly. This book is the first wide-ranging survey of the use of beta blockers in elderly patients. The articles contained herei- written by pharmacologists, cardiologists, sports physicians, neurologists, psychiatrists, and ophthalmologists - show that advanced age alone does not contraindicate the use of beta-blockers and sympatholytic substances. Also provided are guidelines for examination and determination of in dications in the elderly. Both the symposium and the publication of this volume have been kindly supported by Astra Chemicals, West Germany.

I. The Pharmacological Basis of ?-Blocking Agents

?-Blockers: Theory, Action and Application to the Elderly
Pharmacokinetics of ?-Blockers in the Elderly
II. Clinical Aspects
Treatment of Hypertension with ?-Blockers in Elderly Patients
Mechanism of Action of Combined Treatment with ?-Blockers and Diuretics in Elderly Hypertensive Patients
Treatment of Myocardial Infarction with ?-Blockers in Elderly Patients
Secondary Prevention Trials with ?-Blocking Drugs After Myocardial Infarction
?-Receptor Therapy of Cardiac Rhythm Disturbances in Old Age
III. Special Indications
Problems of Physical Activity During Treatment with ?-Blockers
Metabolic Effects of ?-Blockers
The Role of ?-Blockers in Psychiatry and Neurology with Special Reference to Older Patients
Indications for ?-Blockers in Glaucoma Patients.