A comprehensive overview of nanomaterials that are inspired by or targeted at biology, including some of the latest breakthrough research. Throughout, valuable contributions from top-level scientists illustrate how bionanomaterials could lead to novel devices or structures with unique properties. The first and second part cover the most relevant synthetic and bioinspired nanomaterials, including surfaces with extreme wettability properties, functional materials with improved adhesion or structural and functional systems based on the complex and hierarchical organization of natural composites. These lessons from nature are explored in the last section where bioinspired materials are proposed for biomedical applications, showing their potential for future applications in drug delivery, theragnosis, and regenerative medicine. A navigational guide aimed at advanced and specialist readers, while equally relevant for readers in research, academia or private companies focused on high added-value contributions. Young researchers will also find this an indispensable guide in choosing or continuing to work in this stimulating area, which involves a wide range of disciplines, including chemistry, physics, materials science and engineering, biology, and medicine.

Preface PART I: Bionanomaterials SYNTHESIS OF COLLOIDAL GOLD AND SILVER NANOPARTICLES AND THEIR PROPERTIES Introduction Physical and Chemical Properties of Gold and Silver Nanoparticles Synthesis of Gold and Silver Core Nanoparticles Some Applications of Gold and Silver Nanoparticles CERAMIC SMART DRUG DELIVERY NANOMATERIALS Introduction Biodistribution, Toxicity, and Excretion of Nanoparticles Mesoporous Silica Nanoparticles Calcium Phosphate Nanoparticles Carbon Allotropes Iron Oxide Nanoparticles POLYMERSOMES AND THEIR BIOLOGICAL IMPLICATIONS Introduction Self-Assembly of Amphiphiles Polymersome - The Synthetic Analog of a Liposome Polymersomes as Drug Delivery Devices Embedding Channel Proteins in Artificial Polymer Membranes and Creating New Applications Conclusions and Outlook MOFS IN PHARMACEUTICAL TECHNOLOGY Introduction Metal-Organic Frameworks MOFs for Therapeutics Conclusions AMORPHOUS COORDINATION POLYMER PARTICLES FOR BIOMEDICINE Introduction Interaction of Nanoplatforms with the Biological Environment CPPs as Realistic Alternative to Classical Nanosystems Conclusion and Future Challenges MAGNETIC NANOPARTICLES FOR MAGNETIC HYPERTHERMIA AND CONTROLLED DRUG DELIVERY Introduction Principles of Magnetically Induced Heat Generation Sythesis of MNPs and their Heat Performance Local Heating and Induced Biological and Drug Release Effects In Vivo Drug Release from Magnetic Hybrid Systems Under Alternating Magnetic Field Exposure PHOTOTHERMAL EFFECT OF GOLD NANOSTRUCTURES FOR APPLICATION IN BIOIMAGING AND THERAPY Introduction Photophysical Characterizations of Gold Nanostructures Tuning the Absorption Spectrum of Gold Nanostructures Plasmonic Photothermal Effect of GNS in Imaging Concluding Remarks NANOMATERIAL-BASED BIOIMAGING PROBES Introduction Nanoprobes Imaging Probes Targeting Strategies Nanotheranostics Design Considerations Summary and Future Trends MOLECULAR BASES OF NANOTOXICOLOGY Introduction Impact on Environment: Nanoecotoxicology Impact on Health: Nanotoxicology PART II: Bioinspired Materials - Bioinspired Materials for Technological Application BIOINSPIRED INTERFACES FOR SELF-CLEANING TECHNOLOGIES The Concept of Bioinspiration in Materials Engineering Basics of Wetting Self-Cleaning Technologies Summary CATECHOL-BASED BIOMIMETIC FUNCTIONAL MATERIALS AND THEIR APPLICATIONS Introduction Adhesives Functionalizable Platforms (Primers) on Macroscopic Surfaces Micro-/Nanoscopic Surface Functionalization Functional Scaffolds Chelating Materials/Siderophore-Like Materials Materials for Chemo-/Biosensing Electronic Devices CURRENT APPROACHES TO DESIGNING NANOMATERIALS INSPIRED BY MUSSEL ADHESIVE PROTEINS Introduction Mussel Adhesive Proteins and DOPA Nanoparticle Stabilization Nanocomposite Materials Gecko and Mussel Dual Mimetic Adhesive Polydopamine as a Multifunctional Anchor Summary and Future Outlook PART III: Bioinspired Materials - Bioinspired Materials for Biomedical Applications FUNCTIONAL GRADIENTS IN BIOLOGICAL COMPOSITES Introduction Chemical Gradient Hydration Gradient Mineral Gradient Texture Gradient Porosity Gradient Conclusions NOVEL BIOINSPIRED PHOSPHOLIPID POLYMER BIOMATERIALS FOR NANOBIOENGINEERING Introduction Molecular Design of an Artificial Cell Membrane Surface Polymer Nanoparticles System with an Artificial Cell Membrane Structure Nanomaterials Entrapped in the Polymeric Nanoparticles with an Artificial Cell Membrane Future Perspectives BIOINSPIRED FUNCTIONALIZED NANOPARTICLES AS TOOLS FOR DETECTIO, QUANTIFICATION AND TARGETING OF BIOMOLECULES Introduction Bioinspired Functionalized Nanoparticles Biomedical Applications Therapeutics Applications of Nanoparticles Mass Spectrometry and Nanomaterials for Biomolecule Identification Clinical Proteomics and Biomarker Detection Concluding Remarks ENGINEERING PROTEIN BASED NANOPARTICLES FOR APPLICATIONS IN TISSUE ENGINEERING Introduction Inclusion Bodies: Protein-Based Nanoparticles as Novel Bionanomaterials Physicochemical and Nanoscale Properties of Inclusion Bodies Cell Proliferation Assisted by Protein-Based Nanoparticles Microscale Engineering of Protein-Based Nanoparticles for Cell Guidance Conclusions and Perspectives Index

Preface PART I: Bionanomaterials SYNTHESIS OF COLLOIDAL GOLD AND SILVER NANOPARTICLES AND THEIR PROPERTIES Introduction Physical and Chemical Properties of Gold and Silver Nanoparticles Synthesis of Gold and Silver Core Nanoparticles Some Applications of Gold and Silver Nanoparticles CERAMIC SMART DRUG DELIVERY NANOMATERIALS Introduction Biodistribution, Toxicity, and Excretion of Nanoparticles Mesoporous Silica Nanoparticles Calcium Phosphate Nanoparticles Carbon Allotropes Iron Oxide Nanoparticles POLYMERSOMES AND THEIR BIOLOGICAL IMPLICATIONS Introduction Self-Assembly of Amphiphiles Polymersome - The Synthetic Analog of a Liposome Polymersomes as Drug Delivery Devices Embedding Channel Proteins in Artificial Polymer Membranes and Creating New Applications Conclusions and Outlook MOFS IN PHARMACEUTICAL TECHNOLOGY Introduction Metal-Organic Frameworks MOFs for Therapeutics Conclusions AMORPHOUS COORDINATION POLYMER PARTICLES FOR BIOMEDICINE Introduction Interaction of Nanoplatforms with the Biological Environment CPPs as Realistic Alternative to Classical Nanosystems Conclusion and Future Challenges MAGNETIC NANOPARTICLES FOR MAGNETIC HYPERTHERMIA AND CONTROLLED DRUG DELIVERY Introduction Principles of Magnetically Induced Heat Generation Sythesis of MNPs and their Heat Performance Local Heating and Induced Biological and Drug Release Effects In Vivo Drug Release from Magnetic Hybrid Systems Under Alternating Magnetic Field Exposure PHOTOTHERMAL EFFECT OF GOLD NANOSTRUCTURES FOR APPLICATION IN BIOIMAGING AND THERAPY Introduction Photophysical Characterizations of Gold Nanostructures Tuning the Absorption Spectrum of Gold Nanostructures Plasmonic Photothermal Effect of GNS in Imaging Concluding Remarks NANOMATERIAL-BASED BIOIMAGING PROBES Introduction Nanoprobes Imaging Probes Targeting Strategies Nanotheranostics Design Considerations Summary and Future Trends MOLECULAR BASES OF NANOTOXICOLOGY Introduction Impact on Environment: Nanoecotoxicology Impact on Health: Nanotoxicology PART II: Bioinspired Materials - Bioinspired Materials for Technological Application BIOINSPIRED INTERFACES FOR SELF-CLEANING TECHNOLOGIES The Concept of Bioinspiration in Materials Engineering Basics of Wetting Self-Cleaning Technologies Summary CATECHOL-BASED BIOMIMETIC FUNCTIONAL MATERIALS AND THEIR APPLICATIONS Introduction Adhesives Functionalizable Platforms (Primers) on Macroscopic Surfaces Micro-/Nanoscopic Surface Functionalization Functional Scaffolds Chelating Materials/Siderophore-Like Materials Materials for Chemo-/Biosensing Electronic Devices CURRENT APPROACHES TO DESIGNING NANOMATERIALS INSPIRED BY MUSSEL ADHESIVE PROTEINS Introduction Mussel Adhesive Proteins and DOPA Nanoparticle Stabilization Nanocomposite Materials Gecko and Mussel Dual Mimetic Adhesive Polydopamine as a Multifunctional Anchor Summary and Future Outlook PART III: Bioinspired Materials - Bioinspired Materials for Biomedical Applications FUNCTIONAL GRADIENTS IN BIOLOGICAL COMPOSITES Introduction Chemical Gradient Hydration Gradient Mineral Gradient Texture Gradient Porosity Gradient Conclusions NOVEL BIOINSPIRED PHOSPHOLIPID POLYMER BIOMATERIALS FOR NANOBIOENGINEERING Introduction Molecular Design of an Artificial Cell Membrane Surface Polymer Nanoparticles System with an Artificial Cell Membrane Structure Nanomaterials Entrapped in the Polymeric Nanoparticles with an Artificial Cell Membrane Future Perspectives BIOINSPIRED FUNCTIONALIZED NANOPARTICLES AS TOOLS FOR DETECTIO, QUANTIFICATION AND TARGETING OF BIOMOLECULES Introduction Bioinspired Functionalized Nanoparticles Biomedical Applications Therapeutics Applications of Nanoparticles Mass Spectrometry and Nanomaterials for Biomolecule Identification Clinical Proteomics and Biomarker Detection Concluding Remarks ENGINEERING PROTEIN BASED NANOPARTICLES FOR APPLICATIONS IN TISSUE ENGINEERING Introduction Inclusion Bodies: Protein-Based Nanoparticles as Novel Bionanomaterials Physicochemical and Nanoscale Properties of Inclusion Bodies Cell Proliferation Assisted by Protein-Based Nanoparticles Microscale Engineering of Protein-Based Nanoparticles for Cell Guidance Conclusions and Perspectives Index