Bioactive Heterocycles II

Bioactive Heterocycles II

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As part of the series Topics in Heterocyclic Chemistry,this volume titled Bio- tive Heterocycles II presents comprehensive and up-to-date reviews on selected topics regarding synthetic as well as naturally occurring bioactive heterocycles. The ?rst chapter, High Pressure Synthesis of Heterocycles Related to Bio- tive Molecules by Kiyoshi Matsumoto, presents a unique high-pressure s- thetic methodology in heterocyclic chemistry. Basic principles and fruitful examples for pericyclic reactions, such as Diels-Alder reactions, 1,3-dipolar reactions, and also for ionic reactions, such as S and addition reactions, are N discussed. The review will be of considerable interest to heterocyclic chemists and synthetic chemists. The second chapter, Ring Transformation of Nitropyrimidinone Leading to Versatile Azaheterocyclic Compounds by Nagatoshi Nishiwaki and Masahiro Ariga, presents a very critical review on novel ring transformations of di- tropyridones and nitropyrimidinones based on the work of his group. - dressed in this review is the synthesis of functionalized molecules, such as nitroanilines, nitropyridines, and nitrophenols, by the ring transformation of dinitropyridones as the nitromalonaldehyde equivalent. Ring transformations of nitropyrimidinones with dinucleophiles to 4-pyridones, pyrimidines and 4-aminopyridines, and to polyfunctinal pyridones with 1,3-dicarbonyl c- pounds, etc., are also discussed. This review may attract the interest of synthetic chemists as well as heterocyclic chemists in the life science ?elds. The third chapter, Synthesis of Thalidomide by Norio Shibata, Takeshi Yamamoto and Takeshi Toru, describes a modern synthetic aspect of thali- mide.

High-Pressure Synthesis of Heterocycles Related to Bioactive Molecules
Ring Transformation of Nitropyrimidinone Leading to Versatile Azaheterocyclic Compounds
Synthesis of Thalidomide
Rational Drug Design of ? Opioid Receptor Agonist TAN-67 from ? Opioid Receptor Antagonist NTI
Tetrahydrobiopterin and Related Biologically Important Pterins
Preparation, Structure, and Biological Properties of Phosphorus Heterocycles with a C?-?P Ring System
The Role of the Membrane Actions of Phenothiazines and Flavonoids as Functional Modulators.
ISBN 9783642091605
Artikelnummer 9783642091605
Medientyp Buch
Copyrightjahr 2010
Verlag Springer, Berlin
Umfang 309 Seiten
Abbildungen XII, 309 p.
Sprache Englisch