Biocombinatorial Approaches for Drug Finding
Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities.
1;Editors;3 2;Preface;5 3;Contents;8 4;List of Editors and Contriiutors;10 5;1 Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design;18 6;2 Sources of Polyketides and Non-Ribosomal Peptides;36 7;3 Polyketide Synthases: Mechanisms and Models;59 8;4 Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptide Synthetases;95 9;5 Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters;123 10;6 Engineering Glycosylation in Bioactive Compounds by Comiinatorial Biosynthesis;143 11;7 Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds;163 12;8 Enzymatic Incorporation of Halogen Atoms into Natural Compounds;180 13;9 From Glucose to Antiiiotics: What Controls the Fluxes?;210 14;10 Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides;230 15;11 Tool-Box: Tailoring Enzymes for Bio-Comiinatorial Lead Development and as Markers for Genome-Based Natural Product Lead Discovery;248 16;12 Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming;275
Wohlleben, W.
Spelling, T.
Müller-Tiemann, B.
| ISBN | 9783540270553 |
|---|---|
| Artikelnummer | 9783540270553 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2007 |
| Verlag | Springer-Verlag |
| Umfang | 284 Seiten |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
