This book constitutes the refereed proceedings of the First International on Bioinformatics and Computational Biology, BICoB 2007, held in New Orleans, LA, USA, in April 2007. The 30 revised full papers presented together with 10 invited lectures were carefully reviewed and selected from 72 initial submissions. The papers address current research in the area of bioinformatics and computational biology fostering the advancement of computing techniques and their application to life sciences in topics such as genome analysis sequence analysis, phylogenetics, structural bioinformatics, analysis of high-throughput biological data, genetics and population analysis, as well as systems biology.

Invited Talks

Association Analysis Techniques for Bioinformatics Problems
Analyzing and Interrogating Biological Networks (Abstract)
From Architecture to Function (and Back) in Bio-networks
A New Machine Learning Approach for Protein Phosphorylation Site Prediction in Plants
Assembly of Large Genomes from Paired Short Reads
Amino Acid Classification and Hash Seeds for Homology Search
Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads
Gene Networks Viewed through Two Models
Identifying Evolutionarily Conserved Protein Interaction Modules Using GraphHopper
The 2-Interval Pattern Matching Problems and Its Application to ncRNA Scanning
Refereed Papers
RNA Pseudoknot Folding through Inference and Identification Using TAGRNA
Comparing Bacterial Genomes by Searching Their Common Intervals
Generalized Binary Tanglegrams: Algorithms and Applications
Three-Dimensional Multimodality Modelling by Integration of High-Resolution Interindividual Atlases and Functional MALDI-IMS Data
Detecting Motifs in a Large Data Set: Applying Probabilistic Insights to Motif Finding
A Biclustering Method to Discover Co-regulated Genes Using Diverse Gene Expression Datasets
Computational Protocol for Screening GPI-anchored Proteins
Towards Large-Scale Molecular Dynamics Simulations on Graphics Processors
An Agent-Based Model of Solid Tumor Progression
Deciphering Drug Action and Escape Pathways: An Example on Nasopharyngeal Carcinoma
Selection of Multiple SNPs in Case-Control Association Study Using a Discretized Network Flow Approach
Biclustering Expression Data Based on Expanding Localized Substructures
Constrained Fisher Scores Derived from Interaction Profile Hidden Markov Models Improve Protein to Protein InteractionPrediction
Improving Protein Localization Prediction Using Amino Acid Group Based Physichemical Encoding
The Impact of Gene Selection on Imbalanced Microarray Expression Data
Spatial Information and Boolean Genetic Regulatory Networks
Modeling of Genetic Regulatory Network in Stochastic ?-Calculus
fMRI Activation Detection by MultiScale Hidden Markov Model
cnF2freq: Efficient Determination of Genotype and Haplotype Probabilities in Outbred Populations Using Markov Models
A Comprehensive Analysis Workflow for Genome-Wide Screening Data from ChIP-Sequencing Experiments
A Fitness Distance Correlation Measure for Evolutionary Trees
Alignment and Analysis of Closely Related Genomes
Computational Prediction of Genes Translationally Regulated by Cytoplasmic Polyadenylation Elements
Multiple Sequence Alignment System for Pyrosequencing Reads
A Bayesian Approach to High-Throughput Biological Model Generation
Parallel Selection of Informative Genes for Classification
Simulation Methods in Uncovering New Regulatory Mechanisms in Signaling Pathways
GridSPiM: A Framework for Simple Locality and Containment in the Stochastic ?-Calculus
Mutual Information Based Extrinsic Similarity for Microarray Analysis
Graph Spectral Approach for Identifying Protein Domains.