This second edition integrates the more technical and mathematical aspects of bioinformatics with concrete examples of their application to current research problems in molecular, cellular and evolutionary biology. This broad, unified approach is made possible, in large part, by the very wide scope of Dr. Xia's own research experience. The integration of genomics, proteomics and transcriptomics into a single volume makes this book required reading for anyone entering the new and emerging fields of Systems Biology and Evolutionary Bioinformatics.

Blast and Fasta

Sequence alignment
Contig assembly
DNA replication and viral evolution
Gene and motif prediction
Hidden Markov Models
Gibbs Sampler
Bioinformatics and vertebrate mitochondria
Characterizing translation efficiency
Protein isoelectric point
Bioinformatics and Two-Dimensional Protein Separation
Self-Organizing Map and other clustering Algorithms
Molecular Phylogenetics
Fundamentals of Proteomics.