Everyone has heard of nature's "biological clocks", the phenomenon of periodic activity in plants, animals and humans. But what does chronobiology have to do with modern medicine?
This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine.
The chapters are written by specialists in the field; they summarize the physiology, pathophysiology and pathology of the human time structure and outline the application of chronobiologic principles and techniques for diagnosis and treatment.

I Basic Concepts

Biologic Rhythms from Biblical to Modern Times. A Preface
Principles of Clinical Chronobiology
II Mechanisms of Rhythms
Cellular and Molecular Aspects of Circadian Oscillators: Models and Mechanisms for Biological Timekeeping
The Suprachiasmatic Nucleus and Other Pacemakers
Molecular and Genetic Aspects of Chronobiology
Seasonal and Daily Control of Enzyme Synthesis and Activity by Circadian Clocks
III Data Processing
Data Processing in Chronobiological Studies
IV Pharmacology and Toxicology
Chronopharmacology
Chronotoxicology
Rhythms in Drug-Induced Teratogenesis
V Child Development and Aging
Chronobiology of Pregnancy and the Perinatal Time Span
Patterns of Growth Hormone Release During Childhood and Adolescent Development in the Human
Rhythms in Biochemical Variables Related to Bone and Their Regulating Hormones
Biological Rhythms and Aging
VI Physical and Mental Performance
Chronobiology of Mental Performance
Biological, Behavioral and Intellectual Activity Rhythms of the Child During Its Development in Different Educational Environments
Chronobiology of Physical Performance and Sports Medicine
VII Shift Work and Transmeridian Flights
Night and Shift Work and Transmeridian and Space Flights
VIII Sleep
Chronobiology of Human Sleep and Sleep Disorders
IX Psychiatry
The Complex Circadian Pacemaker in Affective Disorders
X Endocrine and Metabolic Functions
Rhythmic and Non-Rhythmic Modes of Anterior Pituitary Hormone Release in Man
Chronobiology of the Hypothalamic-Pituitary-Adrenal and Renin-Angiotensin-Aldosterone Systems
Chronobiology of the Hypothalamic-Pituitary-Gonadal Axis in Men and Women
Chronobiology of the Hypothalamic-Pituitary-Thyroid Axis
The Pineal
Chronobiology of Endocrine-Immune Interactions
Chronobiology, Nutrition, and Diabetes Mellitus
Endocrine and Neuroendocrine Axis Testing in Clinical Medicine: Evidence for Time Dependency
XI Hepatobiliary System
Biological Rhythms in Hepatic Drug Metabolism and Biliary Systems
XII Gastrointestinal System
Chronobiology of the Gastrointestinal System
XIII Cardiovascular System
Cardiovascular Chronobiology and Chronopharmacology
Chronobiologic Blood Pressure Assessment from Womb to Tomb
XIV Respiratory System
Nocturnal Asthma: Mechanisms and Chronotherapy
XV Renal Physiology and Pathology
Renal Excretion: Rhythms in Physiology and Pathology
XVI Inflammatory Reactions
Inflammatory Reaction and Disease States
XVII Immunology and Hematology
Chronobiology of Immune Functions: Cellular and Humoral Aspects....
Chronobiology of Circulating Blood Cells and Platelets
Chronobiology of Human Bone Marrow
Chronobiology of Polymorphonuclear Leukocyte Migration
Chronobiology in Hemostastis
XVIII Cell Proliferation and Cancer
Normal and Abnormal Cell Proliferation in Mice Especially as It Relates to Cancer
Chronobiology of Endocrine and Endocrine-Responsive Tumors
Chronochemotherapy of Malignant Tumors: Temporal Aspects of Antineoplastic Drug Toxicity
Immune System in Relation to Cancer
Rhythms in Tumor Markers
XIX Epidemiology
Chronoepidemiology: Chronobiology and Epidemiology
XX Laboratory Medicine
Chronobiology in Laboratory Medicine.