Die Vor- und Nachteile der Hormonersatztherapie (HRT) werden von einer Expertengruppe hinsichtlich der epidemiologischen Beweislage diskutiert. Obwohl alle positiven und negativen Aspekte der HRT behandelt werden, liegt der Schwerpunkt der Diskussionen bei der Frage des Brustkrebsrisikos. Unter anderem wird gezeigt, dass die aus epidemiologischen Studien abgeleiteten Ergebnisse sich nicht mit den Wachstumseigenschaften dieser Tumoren decken so dass weiterführende Bevölkerungsuntersuchungen unter Einbeziehungen pathobiologischen Sachverstands notwendig erscheinen.

This volume contains an advanced level discussion on the appropriateness of hormone replacement therapy (HRT) in modern postmenopausal women on the basis of the current evidence provided by recent epidemiological studies. It addresses all aspects of benefits and risks associated with HRT, including issues concerning psychology, the cardiovascular system, bone structure, and carcinogenesis. It focuses, however, on cancer risk and on risk of breast cancer in particular. In doing so, it provides a detailed discussion of the pathobiological features of breast cancer, concluding that the evidence provided by epidemiological studies is in conflict with the biological growth features of breast cancer. It advocates further epidemiological studies which incorporate pathobiological assessments.

The Presentations

to the Presentations
Women Between Biology and Civilization
Issues with the Term "Responsibility"
Epidemiology of Selected Diseases in Women
Pathogenesis of Histological Types of Endometrial Cancer
Pathology of the Colon and Ovary
The Progenitor Cell Concept of Proliferative Breast Disease
Indication for HRT: Climacteric Complaints and Osteoporosis
HRT and Cardiovascular Disease in Women
The Million Women Study
Paradigm Shift in Causal Thinking in Epidemiology
Perception and Communication of Risk
Some Thoughts After the Kloster Andechs Workshop, August 2003
The General Discussion
Menopause and the HRT Risk - Benefit Equation: Status and Outlook
Conclusions of the Kloster Andechs Workshop
Workshop Consensus: The State of the Evidence.