Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.

List of Contents

Reverse Genetics of Mononegavirales
Reverse Genetics Systems for the Generation of Segmented Negative-Sense RNA Viruses Entirely from Cloned cDNA
Transcription and Replication of Nonsegmented Negative-Strand RNA Viruses
Orthomyxovirus Replication, Transcription, and Polyadenylation
Escaping from the Cell: Assembly and Budding of Negative-Strand RNA Viruses
Accessory Genes of the Paramyxoviridae, a Large Family of Nonsegmented Negative-Strand RNA Viruses, as a Focus of Active Investigation by Reverse Genetics
Identification and Characterization of Viral Antagonists of Type I Interferon in Negative-Strand RNA Viruses
Toward Novel Vaccines and Therapies Based on Negative-Strand RNA Viruses
Influenza Vaccines Generated by Reverse Genetics.