This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Chapter 1) Definition of "Tissue-based Biomarker", Its Place in Medicine and Molecular Pathology

Chapter 2) The Concept and Mechanisms of Metastasis
Chapter 3) Biomarkers in Skin Carcinomas
Chapter 4) Biomarkers in Head and Neck Carcinomas
Chapter 5) Biomarkers in Pulmonary Carcinomas
Chapter 6) Biomarkers in Endocrine Organ Carcinomas
Chapter 7) Biomarkers in Gastrointestinal System Carcinomas
Chapter 8) Biomarkers in Hepatopancreatobiliary Carcinomas
Chapter 9) Biomarkers in Urinary Tract and Male Genital System Carcinomas
Chapter 10) Biomarkers in Gynecological Carcinomas
Chapter 11) Biomarkers in Breast Carcinomas
Chapter 12) Diagnostic Approach According to More Frequent Metastatic Sites-Liver, Lungs, Bone, Lymph Nodes
Chapter 13) Diagnostic Approach According to Uncovered Metastatic Sites - Mediastinum-Timus, Peritoneum, Central Nervous System, Soft Tissue
Chapter 14) Management of the Patients with Primary Unknown Carcinoma and the Role of Biomarkers.-Chapter 15) Treatment Approach to Carcinomas of Unknown Primary
Appendix.