This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed.

 

Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.

Foreword

Preface
Prologue
 Basic Studies: Tumor Mechanisms and Tissue Biomarkers
The Role of the Tumor Microenvironment in Regulating Angiogenesis
Vessel co-option in melanoma
Tissue Based Biomarkers of Tumor-Vascular Interactions
Molecular phenotypes of endothelial cells in malignant tumors
Lymphatics in malignant tumors
Role of the Extracellular Matrix in Tumor Stroma - Barrier or Support?
Importance of tissue architecture in cancer development and progression
The Tumor Microenvironment as a Target for Therapeutic Modulation and Monitoring
Tumor-fibroblast interactions
Stromal PDGF Receptors as Prognostic and Predictive Biomarkers
Inflammation and Cancer, the Role of Lipid Signalling in the Continuum Between Two Ends of the Tumor Spectrum
Cancer Immunity and Immune Evasion Mechanisms
Drivers of EMT and Immune Evasion
Inflammatory Biomarkers for Cancer
Tumor Infiltrating Lymphocytes: Methods and Guidelines
The Role of Platelets in the Tumor Microenvironment
Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments
Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis
The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance
Imaging mass cytometry in studies of the tumor microenvironment
Artificial intelligence in studies of malignant tumors
Clinical Applications: Organ Related Biomarker Studies
Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Progress in Breast Cancer
MR-Derived Biomarkers for Cancer Characterization
PDX-models and small animal imaging in studies of gynecologic cancers
The Influence of Tissue Architecture on Drug Response: Anti-Cancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms
Models of Tumor Progression in Prostate Cancer
Prostate biomarkers
Immune responses in lung cancer
Tumor-vascular interactions in non-small cell lung cancer
Tumor-Host Interactions in Malignant Glioma
The Tumor Microenvironment in Cutaneous Melanoma - Friend or Foe?
Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy.