Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine

Focusing on key points to better understand extracellular vesicles (EVs) and their development, Biomedical Applications of Extracellular Vesicles describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more.

The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented.

Sample topics covered in Biomedical Applications of Extracellular Vesicles include:

• Biogenesis of various EVs
• Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs
• EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases
• Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method
• Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs
• Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs

Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry, Biomedical Applications of Extracellular Vesicles is an essential resource on the subject for chemists, cell biologists, and molecular physicists.

Dr. Zhenhua Li is Professor at Southern Medical University, China. He serves as an editorial board member of Extracellular Vesicle, Exploration, Materials Today Bio.

Dr. Xing-Jie Liang is Deputy Director of Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences.

Dr. Ke Cheng is a Professor of Biomedical Engineering at Columbia University.