The book is intended to present various examples for reactor and process modeling and control as well as for metabolic flux analysis and metabolic design at an ad vanced level. In Part A, General principles and techniques with regard to reactor and process models, process control, and metabolic flux analysis are presented. In addition the accuracy, precision, and reliability of the measured data are discussed which are ex tremely important for process modeling and control. A virtual bioreactor system is presented as well, which can be used for the training of students and operators of industrial plants and for the development of advanced automation tools. In Part B, the General principles are applied for particular bioreactor models. It covers the application of the computational fluiddynamic (CFD) technique to stirred tank and bubble column bioreactors. Different solution methods are presented: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with an appropriate turbulence (k-ee) model, and the Euler (two fluid model), as well as the Euler-Langrange approaches.

The Need for Modeling and Control in Biotechnical Processes

Some Modeling Basics
Structure and Operation of Biotechnical Plant
References
A General Principles and Techniques
1 Bioreactor Models
2 Bioprocess Models
3 Metabolic Flux Analysis
4 Accuracy and Reliability of Measured Data
5 Bioprocess Control
6 On-Line Simulation Techniques for Bioreactor Control Development
B Application of General Principles for Reactor Models
7 Application of Computational Fluiddynamics (CFD) to Modeling Stirred Tank Bioreactors
8 Bubble Column Bioreactors
C Application of General Principles for Process Models Including Control
9 Baker's Yeast Production
10 Modeling of the Beer Fermentation Process
11 Lactic Acid Production
12 Control Strategies for High-Cell Density Cultivation ofEscherichia coli
13 ?-Lactam Antibiotics Production withPenicillium chrysogenum and Acremonium chrysogenum
D Metabolite Flux Analysis, Metabolic Design
14 Quantitative Analysis of Metabolic and Signaling Pathways inSaccharomyces cerevisiae
15 Metabolic Analysis ofZymomonas mobilis
16 Metabolic Flux Analysis ofCorynebacterium glutamicum
17 Analysis of Metabolic Fluxes in Mammalian Cells.