This book provides a comprehensive overview of the state-of-the-art research as well as current challenges and strategies to reconstruct large bone defects employing 3D printing technology. Various topics covered include different 3D printing technologies that can be applied for bioengineering bone, the aspects of basic bone biology critical for clinical translation, tissue engineering platforms to investigate the bone niche microenvironment, the pathway to clinical translation, and regulatory hurdles.

Bone Tissue Engineering: State-of-the-Art in 3D Printing is an ideal book for students and researchers interested in learning more about the latest advances in employing different 3D printing technologies for bone tissue engineering. 

1. Introduction (market, clinical need, bone grafts) a. Choice 1: Alan S Herford, DDS, MD (Loma Linda University)

2. Basic bone biology a. Choice 1: David T Scadden, MD (Massachusetts General Hospital)
3. Principles of bone tissue engineering a. Choice 1: Antonios G Mikos, PhD (Rice University) b. Choice 2: Susmita Bose, PhD (Washington State University)
4. Additive manufacturing technologies a. Choice 1: Anthony Atala, MD (Wake Forest School of Medicine) b. Choice 2: Jennifer A Lewis, ScD (Harvard University)
5. 3D printing scaffolds for oral and maxillofacial regeneration a. Choice 1: Fernando PS Guastaldi, PhD (Massachusetts General Hospital) and Maria J Troulis, MsC (Massachusetts General Hospital)
6. 3D printing scaffolds for orthopedic joint tissue engineering a. Choice 1: Anthony J Melchiorri, PhD (Rice University)
7. 3D bioprinting and nanotechnology for bone tissue engineering a. Choice 1: Bhushan Mahadik, PhD (University of Maryland)
8. Bioreactors and scale-up in bone tissue engineering a. Choice 1: John P Fisher, PhD (University of Maryland)
9. Commercialization, legal, and regulatory considerations to translate 3D printing-based products to the marketplace and the clinic a. Choice 1: Anthony Ratcliffe, PhD (Synthasome, Inc.)
10. Future directions and challenges a. Choice 1: James J Yoo, PhD (Wake Forest School of Medicine) b. Choice 2: Fernando PS Guastaldi, PhD (Massachusetts General Hospital) and Bhushan Mahadik, PhD (University of Maryland).