1;Foreword;5 2;Contents;10 3;Contributors;35 4;Section 1;54 4.1;1 Role of Modeling in Pharmacotherapeutics;55 5;Section 2;80 5.1;2 PET and Nuclear Medicine Imaging of the Breast;82 5.2;3 Functional Radiologic Imaging in Breast Cancer;93 6;Section 3;111 6.1;4 Prevention of Breast Cancer;113 7;Section 4;145 7.1;5 DCIS: Pathology and Molecular Markers;148 7.2;6 Ductal Carcinoma In Situ: a Modern Approach to Patient Management;173 7.3;7 Ductal Carcinoma In Situ: Systemic Treatment;184 8;Section 5;204 8.1;8 Tailored Surgery for Early Breast Cancer: Surgical Techniques;207 8.2;9 Tailored Surgery for Early Breast Cancer: Biological Aspects;228 8.3;10 Tailored Surgery for Early Breast Cancer: the Very Young Woman;244 8.4;11 Tailored Surgery for Older Women with Breast Cancer;259 9;Section 6;273 9.1;12 Tailored Radiotherapy for Breast Cancer Stages I and II: Technical Aspects;278 9.2;13 Breast Cancer Management in the Era of Molecular Medicine: Tailored Radiotherapy - Clinical and Biological Aspects;300 9.3;14 Early Breast Cancer (Stage I and II): Tailored Radiotherapy for Very Young Women;322 9.4;15 The Elderly and Breast Cancer Radiotherapy;333 10;Section 7;348 10.1;16 Early Breast Cancer (Stage I and Stage II): Tailored Systemic Therapy for Endocrine- Resistant Breast Cancer;350 10.2;17 Early Breast Cancer (Stage I and Stage II): Tailored Systemic Therapy for Endocrine- Responsive Breast Cancer;368 10.3;18 Tailored Therapy for Breast Cancer in Very Young Women;390 10.4;19 Tailored Systemic Therapy for the Elderly Woman;416 11;Section 8;438 11.1;20 Locoregional Therapy Following Neoadjuvant Chemotherapy: an Evolving Paradigm of Treatment Individualization;441 11.2;21 Medical Therapy of Locally Advanced Breast Cancer;467 12;Section 9;488 12.1;22 Metastatic Breast Cancer: Tailored Endocrine Therapy for Premenopausal Women;489 12.2;23 Metastatic Breast Cancer: Tailored Endocrine Therapy for Postmenopausal Women;503 12.3;24 Metastatic Breast Cancer: Tailored Chemotherapy for the Elderly Woman;516 13;Section 10;540 13.1;25 Treatment of Brain Metastases from Breast Cancer;541 13.2;26 Surgical Management of Breast Cancer Liver Metastases;560 13.3;27 Individualization of Bisphosphonate Therapy;579 13.4;28 Breast Cancer Metastases to the Eye;599 13.5;29 Organ-Specific Approaches: Pain Management;602 14;Section 11;625 14.1;30 Genomic and Molecular Classification of Breast Cancer;626 14.2;31 Applications of Proteomics to Clinical Questions in Breast Cancer;653 15;Section 12;670 15.1;32 Targeting the HER Family of Receptors in the Treatment of Advanced Breast Cancer;671 15.2;33 Biological Therapies for Metastatic Breast Cancer: Antiangiogenesis;699 15.3;34 Breast Cancer Gene Therapy;733 15.4;35 Innovative Rational-Derived, Target- Based and Cytotoxic Therapies for Breast Cancer and Other Malignancies;769 16;Section 13;809 16.1;36 Mechanisms of Breast Cancer Resistance to Chemotherapy;810 16.2;37 Mechanisms of Resistance to Hormone Therapy;831 16.3;38 Novel Signaling Pathways in Breast Cancer;848 16.4;39 Mechanisms of Apoptosis Resistance In Breast Cancer;865 17;Section 14;883 17.1;40 Breast Cancer and Pregnancy;886 17.2;41 Hormone Replacement Therapy After Breast Cancer;902 17.3;42 Male Breast Cancer;926 17.4;43 Patients' Preferences: What Makes Treatments Worthwhile?;947 17.5;44 Breast Cancer: the Impact of Depression and its Treatment;967 17.6;45 Molecular Profiling in Breast Cancer;998 17.7;46 Clinical Trials in the Era of Treatment Tailoring;1028 18;Subject Index;1042