The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival.

Preface

Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides
The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology
Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That "Isolates" Repertoires Undergoing Positive or Negative Selection
Selection and Behaviour of CD4+CD25+ T Cells in vivo: Lessons from T Cell Receptor Transgenic Models
Migration Matters: Functional Properties of Naive- and Effector/Memory-Like Regulatory T Cell Subsets
Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells
Dendritic Cells, Key Cells for the Induction of Regulatory T Cells?
Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study or CD4+CD25+ T Cell-Mediated Suppresion
Regulatory T Cells in Experimental Colitis
Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: the Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control
Regulatory T Cells in Transplantation Tolerance. Infectious Tolerance
CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation
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Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells
Subject Index.