This comprehensive book is divided into 6 parts that cover all topics related to cerebrospinal fluid (CSF ) rhinorrea. It provides in-depth theoretical and practical knowledge, and includes teaching material as well as evidence-based scientific content.

The introductory part presents the skull base anatomy, CSF physiology, pathophysiology of skull base defects as well as the role of imaging in this condition. The second and third parts provide details of different diagnostic features and conservative management. The fourth and central part thoroughly illustrates surgical approaches for this clinical condition and follows a similar structure, describing each surgical procedure step-by-step.  The fifth part sheds light on the postoperative management and the long-term follow up, while the last part addresses miscellaneous topics, such as quality of life, outcome measures, and medico-legal issues.

The book is enriched by a wealth of high-quality figures and online videos that illustrate real-world clinical cases, and each chapter features a summary box, key points and a conclusion. The contributors are leading experts in the field and include authorities and inventors of skull base surgical approaches and reconstruction techniques. The multidisciplinary panel of authors - from 6 continents - consists of neurosurgeons, radiologists and anesthesiologists. The book is intended for medical, surgical and paramedic professionals, and is a valuable resource for all levels - from medical students to consultants.

1 Skull base development and anatomy

2 Imaging of skull base
3 Physiology of CSF
4 Pathophysiology of skull base defect and CSF leak
5 Clinical presentation of CSF leak
6 Fluid analysis in rhinorrhea
7 Role of radiology in CSF leak
8 Use of fluorescein
9 Diagnostic algorithm for CSF leak
10 Conservative management of CSF leak
11 Traumatic CSF leaks
12 Spontaneous CSF leaks: Intracranial hypertension, Neoplasms, Idiopathic
13 Multidisciplinary approach to CSF leak
14 History of surgical approaches and techniques for skull base reconstruction
15 Operative room set-up and instrumentation
16 Role of anesthesiologist
17 Synthetic materials for skull base reconstruction
18 Free autologous graft
19 Local pedicled flaps
20 Regional pedicled flap
21 Micro-vascular free flap
22 Anterior cranial fossa CSF leak repair
23 Middle & Posterior cranial fossa CSF leak repair
24 The proper use of reconstructive material
25 External approaches for skull base reconstruction
26 Post-operative instructions
27 Surgical complications of skull base reconstruction
28 Failure of CSF leak repair
29 Role of lumbar drain in CSF leak
30 Long-term follow up strategy
31 Pediatric CSF leak
32 Outcomes of skull base reconstruction
33 Abnormal presentation of CSF leak
34 Management of benign intracranial hypertension
35 Evidence based medicine in CSF leak and skull base reconstruction
36 Quality of life and Outcome measures in CSF leak
37 Surgical competence in CSF leak repair
38 Patients advocacy and medico-legal issues.