This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field.

In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging. Cancer Immunology: A Translational Medicine Context will be of special value to clinical immunologists, hematologists, and oncologists.

Introduction on cancer immunology and immunotherapy

Inflammatory and innate immune cells in cancer microenvironment and progression
Role of innate immunity in cancers and antitumor response
Role of B cells in anti tumor response
The role of exhaustion in tumor-induced T cell dysfunction in patients with cancer
Regulatory T cells and Th17 cells in the immunosuppressive tumor network
Role of cytokines in tumor immunity and immune tolerance to cancers
Role of chemokines and chemokine receptors in cancers
The role of Fas and Fas-ligand in cancers
MHC class I molecules and cancer progression: Lessons learned from preclinical tumor models
Role of plasmacytoid dendritic cells in cancer
Cancer immunoediting: immunosurveillance, immuneequilibrium, and immune escape
Apoptosis, autophagy and necroptosis in Cancer
Prognostic value of innate and adaptive immunity in cancers
Epigenetics and Micro RNAs in cancers
Immunogenetics of cancers
Immunodeficiencies and cancers
Immunosenescence and cancers
Nutrition, immunity and cancers
Allergies and cancers
Cancer immunology of transmissible cancers
Systems biology and systems immunology of cancer
Principles of immunological diagnostic tests for cancers
Flow cytometry in cancer immunotherapy: applications, analysis, quality control and future
Immunohistochemistry of cancers
Immunology and immunotherapy of graft versus host disease.