A variety of new cancer therapy modalities are discussed and evaluated in this book. It aims to demonstrate that the combination of classical chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-CSF and monoclonal antibodies against gastrointestinal tumors and melanoma are included. The progress in regional chemotherapy strategies, for example of the liver, is shown. In addition, the development of new chemotherapeutic agents with a different mode of action as well as better tolerability is presented. The use of hormones, such as LH-RH agonists, allows hormone-dependent tumors such as prostatic and breast cancer to be treated without strong adverse reactions. These recent findings give the reader insight into exciting therapeutic directions made possible by such combined, rather than single, modalities.

Monoclonal Antibodies

Immunochemotherapy of Cancer: A Perspective
Quantitative Considerations Supporting the Irrelevance of Circulating Serum Carcinoembryonic Antigen for the Immunoscintigraphic Visualization of Carcinoembryonic Antigen-Expressing Carcinomas
Radioimmunotherapy with Iodine 131-Labelled Antibodies in Ovarian, Colonic and Brain Tumours
Radioimmunodetection and Radioimmunotherapy in Myosarcoma
Immunotherapy of Pancreatic Cancer with Monoclonal Antibody BW 494: Results from a Multicentric Phase I-II Trial
Mab 17-1A Used for Therapy of Patients with Metastatic Colorectal Carcinomas
Immunotherapy of Malignant Melanomas
Interaction of Monoclonal Antibodies with Biological Response Modifiers and Cytostatics
Lymphokines
Cancer Treatment with Cytokines: Concepts and First Clinical Experience
Low-dose Cyclophosphamide and IL-2 in the Treatment of Advanced Melanoma
Application of Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Malignant Hematological Diseases
Enhancement of Autologous Bone Marrow Transplantation with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhGM-CSF)
A Phase lb Evaluation of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor
The Role of Interferon in the Management of Patients with Hairy Cell Leukemia and Multiple Myeloma
Possible Mechanism of Interferon Action in Hairy Cell Leukemia
Tumor Vaccination in the Treatment of Colorectal Cancer
New Approaches in Surgical Oncology
New Developments in Surgical Oncology
Cancer Surgery - Conservative or Radical?
Regional Chemotherapy of the Liver and Hepatic Artery Occlusion
Regional Chemotherapy of Hepatic Metastases
Regional Chemotherapy in Hepatic Metastases of Colorectal Carcinoma: ContinuousIntra-arterial Versus Continuous Intra-arterial/Intravenous Therapy
Isolated Regional Hyperthermal Liver Perfusion: Indications, Technique and Results
Chemoembolization of Liver Tumors
New Cancer Treatment with Lasers - Photodynamic Therapy and Interstitial Hyperthermia
Specificity, Kinetics, and Distribution of Monoclonal Antibodies to Carcinoembryonic Antigen in Human Colorectal Carcinoma by Ex Vivo Human Tumor Perfusion
Chemotherapy and Hormonal Therapy
Chemotherapy: Benefits and Limits
The Human Tumor Clonogenic Assay for the Prediction of Tumor Sensitivity
Chemosensitivity: Directed Regional Chemotherapy of Liver Metastases
Clinical Development of New Anthracyclines
First Clinical Experience with Cytorhodin S - The First Compound of a New Class of Anthracyclines
Pirarubicin: A New Drug in the Treatment of Malignant Diseases
Pirarubicin - A New Anthracycline with High Activity in Untreated Patients with Small-Cell Cancer of the Lung
New Approaches in the Hormonal Therapy of Breast Cancer.
Reproductive Toxicity with and Without Administration of Luteinizing-Hormone-Releasing Hormone Agonist During Adjuvant Chemotherapy in Patients with Germ Cell Tumors.